São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil.
Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brazil.
J Pharm Biomed Anal. 2022 Sep 20;219:114975. doi: 10.1016/j.jpba.2022.114975. Epub 2022 Jul 29.
Turnera ulmifolia L. is used in folk medicine and it is known to have anti-hyperglycemic effect on the organism in order to reduce complications in diabetic patients. Glycation process is directly related to oxidative stress, acting as an important endogenous source, inducing the production of free radicals, and thus increasing the production of reactive oxygen species. The encapsulation technology on natural compounds can minimize and even mitigate the risk of loss of biological activity in order to maintain their activities against oxidative stress and glycation. The present study aimed to evaluate the antiglycation and antioxidant activities of T. ulmifolia extract before and after encapsulation and cytotoxicity of the crude extract. This study presents important information about the biological activities, highlighting antioxidant and antiglycation potential and no cytotoxicity of Turnera ulmifolia crude extract, a species of genus Turnera that has been poorly studied. T. ulmifolia crude extract presented flavonoids as main active compounds. The results showed a promising activity in scavenging free and peroxyl radicals, chelating iron ions and inhibiting BSA glycation. In addition, this study showed the possible encapsulation of bioactive compounds using maltodextrin as wall material.
Turnera ulmifolia L. 在民间医学中被使用，已知其对机体具有抗高血糖作用，以减少糖尿病患者的并发症。糖基化过程与氧化应激直接相关，作为一个重要的内源性来源，诱导自由基的产生，从而增加活性氧的产生。对天然化合物进行包封技术可以最小化甚至减轻生物活性损失的风险，以保持其对氧化应激和糖基化的活性。本研究旨在评估封装前后 T. ulmifolia 提取物的抗糖化和抗氧化活性以及粗提取物的细胞毒性。本研究提供了关于生物活性的重要信息，突出了抗氧化和抗糖化潜力以及对 Turnera ulmifolia 粗提取物的细胞毒性，该物种的 Turnera 属研究甚少。T. ulmifolia 粗提取物中含有类黄酮作为主要活性化合物。结果表明，该提取物在清除自由基和过氧自由基、螯合铁离子以及抑制 BSA 糖基化方面具有有前景的活性。此外，该研究还表明，使用麦芽糊精作为壁材料可以对生物活性化合物进行可能的包封。
