Precision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Neurosci Biobehav Rev. 2022 Sep;140:104806. doi: 10.1016/j.neubiorev.2022.104806. Epub 2022 Aug 1.
Limited studies have been conducted to explore the interaction effects of social environmental and genetic factors on the risks of common psychiatric disorders.
56,613-106,695 individuals were collected from the UK Biobank cohort. Logistic or liner regression models were first used to evaluate the associations of index of multiple deprivation (IMD) with bipolar disorder (BD), depression and anxiety in UK Biobank cohort. Then, for the significant IMD associated with BD, depression and anxiety, genome-wide gene-environment interaction study (GWEIS) was performed by PLINK 2.0.
Totally, the higher levels of IMD were significantly associated with higher risks of BD, depression and anxiety. For BD, GWEIS identified multiple significant SNPs interacting with IMD, such as rs75182167 for income and rs111841503 for education. For depression and anxiety, GWEIS found significant SNPs interacting with income and education, such as rs147013419 for income and rs142366753 for education.
Social environmental deprivations contributed to the risks of psychiatric disorders. Besides, we reported multiple candidate genetic loci interacting with IMD, providing novel insights into the biological mechanism.
目前，关于社会环境和遗传因素对常见精神障碍风险的交互作用的研究还很有限。
从英国生物库队列中收集了 56613-106695 名个体。首先使用逻辑或线性回归模型来评估英国生物库队列中剥夺指数（IMD）与双相情感障碍（BD）、抑郁和焦虑之间的关联。然后，对于与 BD、抑郁和焦虑显著相关的 IMD，通过 PLINK 2.0 进行全基因组基因-环境交互作用研究（GWEIS）。
总体而言，较高水平的 IMD 与 BD、抑郁和焦虑的风险增加显著相关。对于 BD，GWEIS 鉴定出多个与 IMD 相互作用的显著 SNP，例如与收入相关的 rs75182167 和与教育相关的 rs111841503。对于抑郁和焦虑，GWEIS 发现与收入和教育相互作用的显著 SNP，例如与收入相关的 rs147013419 和与教育相关的 rs142366753。
社会环境剥夺导致了精神障碍的风险增加。此外，我们报告了多个与 IMD 相互作用的候选遗传位点，为生物学机制提供了新的见解。
