Department of Microbiology, Faculty Science, Jahrom Branch, Islamic Azad University, Jahrom, Iran.
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Travel Med Infect Dis. 2022 Sep-Oct;49:102414. doi: 10.1016/j.tmaid.2022.102414. Epub 2022 Aug 2.
Viral infectious diseases have various neurological manifestations, whether they are epidemic or pandemic in nature. Nonspecific encephalopathy is the most common central nervous system (CNS) manifestation. The spectrum of nervous evidence varies for viral pathogens. Some infectious viruses, such as the Ebola virus, exhibit direct neurotropism. Others, such as the Rift Valley fever virus, have the potential for neurotropism. Direct neurotropism is unknown in monkeypox virus, SARS-CoV-2, MERS-CoV, and even smallpox. As seen in the COVID-19, there may be evidence of para-infectious neurological syndrome. There have only been a few reports of neurological diseases caused by monkeypox infection. Future efforts to prevent the spread of infectious disease surges can reduce mortality complications, the therapeutic burden on the health-care system, and prevent further spread. This study describes the clinical and neurological complications of monkeypox infection, particularly encephalitis, as well as the laboratory diagnosis of these cases.
病毒性传染病具有各种神经表现，无论其性质是流行还是大流行。非特异性脑炎是最常见的中枢神经系统（CNS）表现。神经证据的范围因病毒病原体而异。一些传染性病毒，如埃博拉病毒，表现出直接的嗜神经性。其他病毒，如裂谷热病毒，具有潜在的嗜神经性。猴痘病毒、SARS-CoV-2、MERS-CoV 甚至天花都没有直接的嗜神经性。如 COVID-19 所见，可能存在副感染性神经综合征的证据。只有少数关于猴痘感染引起的神经系统疾病的报告。未来努力预防传染病浪潮的传播，可以降低死亡率并发症、医疗保健系统的治疗负担，并防止进一步传播。本研究描述了猴痘感染的临床和神经并发症，特别是脑炎，以及这些病例的实验室诊断。
