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基于全基因组表达数据集的博弈论链接相关性索引确定了具有潜在病因学和治疗作用的结直肠癌潜在显著基因。

Game-theoretic link relevance indexing on genome-wide expression dataset identifies putative salient genes with potential etiological and diapeutics role in colorectal cancer.

机构信息

Centre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh, 786004, Assam, India.

Department of Mathematics, Dibrugarh University, Dibrugarh, 786004, Assam, India.

出版信息

Sci Rep. 2022 Aug 4;12(1):13409. doi: 10.1038/s41598-022-17266-0.

DOI:10.1038/s41598-022-17266-0
PMID:35927308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9352798/
Abstract

Diapeutics gene markers in colorectal cancer (CRC) can help manage mortality caused by the disease. We applied a game-theoretic link relevance Index (LRI) scoring on the high-throughput whole-genome transcriptome dataset to identify salient genes in CRC and obtained 126 salient genes with LRI score greater than zero. The biomarkers database lacks preliminary information on the salient genes as biomarkers for all the available cancer cell types. The salient genes revealed eleven, one and six overrepresentations for major Biological Processes, Molecular Function, and Cellular components. However, no enrichment with respect to chromosome location was found for the salient genes. Significantly high enrichments were observed for several KEGG, Reactome and PPI terms. The survival analysis of top protein-coding salient genes exhibited superior prognostic characteristics for CRC. MIR143HG, AMOTL1, ACTG2 and other salient genes lack sufficient information regarding their etiological role in CRC. Further investigation in LRI methodology and salient genes to augment the existing knowledge base may create new milestones in CRC diapeutics.

摘要

结直肠癌（CRC）的治疗基因标志物有助于控制该疾病导致的死亡率。我们应用博弈论的关联关联度指数（LRI）评分对高通量全基因组转录组数据集进行评分，以鉴定 CRC 中的显著基因，并获得了 126 个 LRI 评分大于零的显著基因。生物标志物数据库缺乏关于所有可用癌症细胞类型的显著基因作为生物标志物的初步信息。显著基因揭示了主要生物过程、分子功能和细胞成分的十一个、一个和六个过表达。然而，在显著基因中没有发现与染色体位置有关的富集。KEGG、Reactome 和 PPI 术语观察到显著的高富集。顶级蛋白编码显著基因的生存分析显示出对 CRC 较好的预后特征。MIR143HG、AMOTL1、ACTG2 和其他显著基因缺乏关于它们在 CRC 中的病因作用的充分信息。进一步研究 LRI 方法和显著基因以增加现有知识库可能在 CRC 治疗学方面创造新的里程碑。

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Front Oncol. 2021 Dec 20;11:765329. doi: 10.3389/fonc.2021.765329. eCollection 2021.
2
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
3
An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes.
一种综合的多组学方法，用于鉴定癌症转移过程中的调控机制。
Genome Biol. 2021 Jan 7;22(1):19. doi: 10.1186/s13059-020-02213-x.
4
Integrated computational approach toward discovery of multi-targeted natural products from Thumbai () for attuning NKT cells.从Thumbai（）中发现用于调节NKT细胞的多靶点天然产物的综合计算方法。
J Biomol Struct Dyn. 2022 Apr;40(7):2893-2907. doi: 10.1080/07391102.2020.1844056. Epub 2020 Nov 12.
5
Role of ion channels in gastrointestinal cancer.离子通道在胃肠道癌症中的作用。
World J Gastroenterol. 2019 Oct 14;25(38):5732-5772. doi: 10.3748/wjg.v25.i38.5732.
6
Compendiums of cancer transcriptomes for machine learning applications.癌症转录组学纲要，用于机器学习应用。
Sci Data. 2019 Oct 8;6(1):194. doi: 10.1038/s41597-019-0207-2.
7
Colorectal Cancer and Metabolism.结直肠癌与代谢
Curr Colorectal Cancer Rep. 2018 Dec;14(6):226-241. doi: 10.1007/s11888-018-0420-y. Epub 2018 Nov 16.
8
A comprehensive study on genome-wide coexpression network of KHDRBS1/Sam68 reveals its cancer and patient-specific association.全面研究 KHDRBS1/Sam68 全基因组共表达网络揭示其与癌症和患者的关联。
Sci Rep. 2019 Jul 31;9(1):11083. doi: 10.1038/s41598-019-47558-x.
9
Passengers masquerading as cancer drivers.伪装成癌症驱动因素的乘客。
Nat Rev Cancer. 2019 Sep;19(9):485. doi: 10.1038/s41568-019-0184-y.
10
Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment.癌症相关成纤维细胞构建并稳固肿瘤微环境。
Front Cell Dev Biol. 2019 Apr 24;7:60. doi: 10.3389/fcell.2019.00060. eCollection 2019.