Abdelazim Mohamed H, Abdelazim Ahmed H, Moneir Waleed
Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr CityCairo, 11751, Egypt.
Allergy Asthma Clin Immunol. 2022 Aug 4;18(1):67. doi: 10.1186/s13223-022-00711-0.
Olfactory dysfunction is recognized as a symptom of COVID-19. Reports revealed the nasal calcium increase has adverse effects on olfactory function. Tetra sodium pyrophosphate, a chelating agent, can bind calcium and help improve olfaction.
Sixty-four patients with olfactory dysfunction persisting for more than 90 days after COVID-19 were recruited. Participants were divided into 2 groups that received either 0.9% sodium chloride or 1% tetra sodium pyrophosphate for topical application. Olfactory function was tested with the Sniffin' Sticks test before treatment and 1 month later. In addition, nasal calcium was determined with an ion-selective electrode.
After topical application of tetra sodium pyrophosphate compared to sodium chloride, improvement from anosmia to hyposmia with decrease in calcium level was demonstrated. As for the results of tetra-sodium pyrophosphate, 81% showed improved olfactory function and 19% did not exhibit olfaction improvement.
Intranasal application of tetra sodium pyrophosphate may be associated with improvement in olfactory function after COVID -19 infection. Trial registration Ethical Committee of Damietta Faculty of Medicine approved this study on January 2021 (approval number, IRB 00012367-21-03-010).
嗅觉功能障碍被认为是新型冠状病毒肺炎（COVID-19）的一种症状。报告显示鼻腔钙增加对嗅觉功能有不良影响。焦磷酸四钠作为一种螯合剂，可结合钙并有助于改善嗅觉。
招募了64例COVID-19后嗅觉功能障碍持续超过90天的患者。参与者被分为两组，分别接受0.9%氯化钠或1%焦磷酸四钠进行局部应用。在治疗前和1个月后用嗅棒测试法测试嗅觉功能。此外，用离子选择性电极测定鼻腔钙含量。
与氯化钠相比，局部应用焦磷酸四钠后，嗅觉从嗅觉丧失改善为嗅觉减退，同时钙水平降低。至于焦磷酸四钠的结果，81%的患者嗅觉功能得到改善，19%的患者嗅觉未得到改善。
COVID-19感染后经鼻应用焦磷酸四钠可能与嗅觉功能改善有关。试验注册 达米埃塔医学院伦理委员会于2021年1月批准了本研究（批准号，IRB 00012367-21-03-010）。
