Roberts-Thomson P J, Langhans T, McEvoy R, Hollingsworth P N, Bonifacio E, Dawkins R L, Bradley J
Ann Rheum Dis. 1987 May;46(5):417-20. doi: 10.1136/ard.46.5.417.
A programme for rheumatoid factor (RF) measurement was sponsored by the South East Asian Pacific League against Rheumatism (SEAPAL) and the Clinical Immunology Group (CIG) of the Australian Society for Immunology. Measurements in 29 laboratories in 12 countries showed: a large variety of methods were being used to measure RF, most using semiquantitative agglutination techniques; some laboratories have invalid techniques; the quoted upper normal limit varied considerably between assays, and false positives were identified in three laboratories; a wide range of intralaboratory precision within and between assays; and a reduction in discordance between laboratories by the inclusion of local standards. Before international standardisation of RF measurement can be achieved attention to many of these problems is required. In particular we recommend the wider use of reference standards and the regular participation in quality control programmes in order to monitor performance.
一项类风湿因子（RF）测量计划由东南亚太平洋抗风湿联盟（SEAPAL）和澳大利亚免疫学会临床免疫学组（CIG）发起。对12个国家29个实验室的测量结果显示：测量RF使用了多种方法，大多数采用半定量凝集技术；一些实验室的技术无效；不同检测方法所引用的正常上限差异很大，且在三个实验室中发现了假阳性结果；各检测方法内部和之间的实验室内精密度范围较宽；通过采用当地标准，实验室之间的不一致性有所降低。在实现RF测量的国际标准化之前，需要关注其中的许多问题。我们特别建议更广泛地使用参考标准，并定期参与质量控制计划，以监测性能。
