Lim Chungun, Lee Peter C W, Shim Sungbo, Jang Sung-Wuk
Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
Oncol Lett. 2022 Jul 1;24(2):290. doi: 10.3892/ol.2022.13410. eCollection 2022 Aug.
The transcription factor or tumor suppressor protein p53 regulates numerous cellular functions, including cell proliferation, invasion, migration, senescence and apoptosis, in various types of cancer. HS-1793 is an analog of resveratrol, which exhibits anti-cancer effects on various types of cancer, including breast, prostate, colon and renal cancer, and multiple myeloma. However, to the best of our knowledge, the role of HS-1793 in lung cancer remains to be examined. The present study aimed to investigate the anti-cancer effect of HS-1793 on lung cancer and to determine its association with p53. The results revealed that HS-1793 reduced cell proliferation in lung cancer and increased p53 stability, thereby elevating the expression levels of the target genes p21 and mouse double minute 2 homolog (MDM2). When the levels of MDM2, a negative regulator of p53, are increased under normal conditions, MDM2 binds and degrades p53; however, HS-1793 inhibited this binding, confirming that p53 protein stability was increased. In conclusion, the findings of the present study provide new evidence that HS-1793 may inhibit lung cancer proliferation by disrupting the p53-MDM2 interaction.
转录因子或肿瘤抑制蛋白p53在各类癌症中调节众多细胞功能，包括细胞增殖、侵袭、迁移、衰老和凋亡。HS-1793是白藜芦醇的类似物，对包括乳腺癌、前列腺癌、结肠癌、肾癌和多发性骨髓瘤在内的多种癌症均具有抗癌作用。然而，据我们所知，HS-1793在肺癌中的作用仍有待研究。本研究旨在探讨HS-1793对肺癌的抗癌作用，并确定其与p53的关联。结果显示，HS-1793可降低肺癌细胞的增殖，并增加p53的稳定性，从而提高靶基因p21和小鼠双微体2同源物（MDM2）的表达水平。在正常情况下p53的负调节因子MDM2水平升高时，MDM2会结合并降解p53；然而，HS-1793抑制了这种结合，证实p53蛋白稳定性增加。总之，本研究结果提供了新的证据，表明HS-1793可能通过破坏p53-MDM2相互作用来抑制肺癌增殖。
