Chen Meiwen, Jiang Rui, Deng Niping, Zhao Xiumin, Li Xiangjuan, Guo Chengchen
Hangzhou Women's Hospital, Hangzhou, Zhejiang.
School of Engineering, Westlake University, Hangzhou, Zhejiang.
Front Bioeng Biotechnol. 2022 Jul 19;10:954699. doi: 10.3389/fbioe.2022.954699. eCollection 2022.
Soft tissues such as skin, muscle, and tendon are easily damaged due to injury from physical activity and pathological lesions. For soft tissue repair and regeneration, biomaterials are often used to build scaffolds with appropriate structures and tailored functionalities that can support cell growth and new tissue formation. Among all types of scaffolds, natural polymer-based scaffolds attract much attention due to their excellent biocompatibility and tunable mechanical properties. In this comprehensive mini-review, we summarize recent progress on natural polymer-based scaffolds for soft tissue repair, focusing on clinical translations and materials design. Furthermore, the limitations and challenges, such as unsatisfied mechanical properties and unfavorable biological responses, are discussed to advance the development of novel scaffolds for soft tissue repair and regeneration toward clinical translation.
诸如皮肤、肌肉和肌腱等软组织很容易因体育活动损伤和病理病变而受损。对于软组织修复和再生，生物材料常被用于构建具有合适结构和定制功能的支架，以支持细胞生长和新组织形成。在所有类型的支架中，天然聚合物基支架因其优异的生物相容性和可调节的机械性能而备受关注。在这篇全面的小型综述中，我们总结了天然聚合物基支架用于软组织修复的最新进展，重点关注临床转化和材料设计。此外，还讨论了诸如机械性能不理想和生物反应不佳等局限性和挑战，以推动用于软组织修复和再生的新型支架向临床转化发展。
