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3D生物打印人工皮肤的治疗效果

Therapeutic Efficacy of Artificial Skin Produced by 3D Bioprinting.

作者信息

Jang Kwang-Sik, Park Soon-Jung, Choi Jong-Jin, Kim Ha-Na, Shim Kyung-Mi, Kim Mi-Jeong, Jang Il-Ho, Jin Song-Wan, Kang Seong-Soo, Kim Se-Eun, Moon Sung-Hwan

机构信息

Department of Veterinary Surgery, College of Veterinary Medicine and Biomaterial R&BD Center, Chonnam National University, Gwangju 61186, Korea.

Pangyo Research Center, T&R Biofab Co., Ltd, Seongnam-si 13487, Korea.

出版信息

Materials (Basel). 2021 Sep 9;14(18):5177. doi: 10.3390/ma14185177.

DOI:10.3390/ma14185177
PMID:34576409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8467964/
Abstract

The skin protects the body from external barriers. Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. Herein, we fabricated a structure similar to the skin layer by using skin-derived decellularized extracellular matrix (dECM) with bioink, keratinocytes, and fibroblasts using 3D-printing technology. The therapeutic effects of the produced skin were analyzed using a chimney model that mimicked the human wound-healing process. The 3D-printed skin substitutes exhibited rapid re-epithelialization and superior tissue regeneration effects compared to the control group. These results are expected to aid the development of technologies that can provide customized skin-replacement tissues produced easily and quickly via 3D-printing technology to patients.

摘要

皮肤保护身体免受外部屏障的侵害。在快速制备对大面积烧伤和皮肤移植手术具有治疗效果的皮肤替代物的技术发展方面存在一定局限性。在此，我们使用皮肤来源的脱细胞细胞外基质（dECM）与生物墨水、角质形成细胞和成纤维细胞，通过3D打印技术制造了一种类似于皮肤层的结构。使用模拟人类伤口愈合过程的烟囱模型分析所产生皮肤的治疗效果。与对照组相比，3D打印的皮肤替代物表现出快速的上皮再形成和优异的组织再生效果。这些结果有望有助于开发能够通过3D打印技术为患者轻松快速地提供定制皮肤替代组织的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/550e771e68d6/materials-14-05177-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/9944365672c4/materials-14-05177-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/314942833feb/materials-14-05177-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/6441a9c5e9d9/materials-14-05177-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/b65326550caf/materials-14-05177-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/c2d8aa2c1737/materials-14-05177-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/0bf75966e890/materials-14-05177-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/6149fedbcc29/materials-14-05177-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/550e771e68d6/materials-14-05177-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/9944365672c4/materials-14-05177-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/314942833feb/materials-14-05177-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/6441a9c5e9d9/materials-14-05177-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/b65326550caf/materials-14-05177-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/c2d8aa2c1737/materials-14-05177-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/0bf75966e890/materials-14-05177-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/6149fedbcc29/materials-14-05177-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e98/8467964/550e771e68d6/materials-14-05177-g008.jpg

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