极低频脉冲电磁场是否适用于脑胶质瘤？极低频脉冲电磁场的潜在机制及应用的文献回顾。
Is extremely low frequency pulsed electromagnetic fields applicable to gliomas? A literature review of the underlying mechanisms and application of extremely low frequency pulsed electromagnetic fields.
机构信息
Cancer Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Cancer Med. 2023 Feb;12(3):2187-2198. doi: 10.1002/cam4.5112. Epub 2022 Aug 5.
Abstract
Gliomas refer to a group of complicated human brain tumors with a low 5-year survival rate and limited therapeutic options. Extremely low-frequency pulsed electromagnetic field (ELF-PEMF) is a specific magnetic field featuring almost no side effects. However, the application of ELF-PEMF in the treatment of gliomas is rare. This review summarizes five significant underlying mechanisms including calcium ions, autophagy, apoptosis, angiogenesis, and reactive oxygen species, and applications of ELF-PEMF in glioma treatment from a clinical practice perspective. In addition, the prospects of ELF-PEMF in combination with conventional therapy for the treatment of gliomas are reviewed. This review benefits any specialists, especially oncologists, interested in this new therapy because it can help treat patients with gliomas properly.
摘要
神经胶质瘤是一组复杂的人类脑肿瘤，其 5 年生存率低，治疗选择有限。极低频脉冲电磁场（ELF-PEMF）是一种具有几乎无副作用的特殊磁场。然而，ELF-PEMF 在治疗神经胶质瘤中的应用却很少。本综述从临床实践的角度总结了 ELF-PEMF 治疗神经胶质瘤的五个重要的潜在机制，包括钙离子、自噬、细胞凋亡、血管生成和活性氧，以及 ELF-PEMF 的应用。此外，还综述了 ELF-PEMF 与传统疗法联合治疗神经胶质瘤的前景。本综述有助于任何对此新疗法感兴趣的专家，特别是肿瘤学家，因为它可以帮助正确治疗神经胶质瘤患者。
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