2022 年 3 月，瑞士在加强针接种运动以及德尔塔和奥密克戎浪潮后，普通人群对 SARS-CoV-2 的功能性免疫。
Functional immunity against SARS-CoV-2 in the general population after a booster campaign and the Delta and Omicron waves, Switzerland, March 2022.
机构信息
Università della Svizzera Italiana, Facoltà di scienze biomediche, Lugano, Ticino, Switzerland.
Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland.
出版信息
Euro Surveill. 2022 Aug;27(31). doi: 10.2807/1560-7917.ES.2022.27.31.2200561.
Functional immunity (defined here as serum neutralising capacity) critically contributes to conferring protection against SARS-CoV-2 infection and severe COVID-19. This cross-sectional analysis of a prospective, population-based cohort study included 1,894 randomly-selected 16 to 99-year-old participants from two Swiss cantons in March 2022. Of these, 97.6% (95% CI: 96.8-98.2%) had anti-spike IgG antibodies, and neutralising capacity was respectively observed for 94%, 92% and 88% against wild-type SARS-CoV-2, Delta and Omicron variants. Studying functional immunity to inform and monitor vaccination campaigns is crucial.
功能性免疫（在此定义为血清中和能力）对预防 SARS-CoV-2 感染和严重 COVID-19 至关重要。这项前瞻性、基于人群的队列研究的横断面分析纳入了 2022 年 3 月瑞士两个州的 1894 名随机选择的 16 至 99 岁参与者。其中，97.6%（95%CI：96.8-98.2%）具有抗刺突 IgG 抗体，分别观察到针对野生型 SARS-CoV-2、Delta 和 Omicron 变体的中和能力为 94%、92%和 88%。研究功能性免疫以提供信息和监测疫苗接种活动至关重要。
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