Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China.
ACS Appl Mater Interfaces. 2022 Aug 17;14(32):36947-36956. doi: 10.1021/acsami.2c08406. Epub 2022 Aug 5.
Bacterial infection is seriously threatening human health, and the design of high-efficiency and good biocompatibility antibacterial agents is an urgent problem to be solved. However, with the emergence of drug-resistant bacteria, the existing antibacterial agents have low killing efficiency, and the formation of biofilms has further weakened the therapeutic effect. Herein, we constructed an efficient antibacterial system mediated by near-infrared light for synergistic antibacterial and biofilm dissipation. Specifically, the ZnO/TiCT with heterojunction was synthesized by hydrothermal growth of ZnO on the surface of lamellar TiCT-MXene. The prepared ZnO/TiCT had better photothermal ability than ZnO and TiCT, respectively. The local thermal effect can not only destroy the integrity of the bacterial membrane but also promote the release of Zn ions and further improve the antibacterial performance. ZnO/TiCT achieved a 100% sterilization rate (better than either ZnO or TiCT) at 150 μg mL. The biofilm dissipation experiment further proved its excellent biofilm ablation effect. More importantly, the results of cell culture and animal experiments have demonstrated its good biological safety. In summary, this new type of nanomaterial shows strong local chemical photothermal sterilization ability and has great potential to replace traditional antibacterial agents.
细菌感染严重威胁人类健康，设计高效、良好生物相容性的抗菌剂是亟待解决的问题。然而，随着耐药菌的出现，现有的抗菌剂杀菌效率低，生物膜的形成进一步削弱了治疗效果。在此，我们构建了一种由近红外光介导的高效抗菌体系，用于协同抗菌和生物膜消解。具体而言，通过在层状 TiCT-MXene 表面水热生长 ZnO 合成了具有异质结的 ZnO/TiCT。与 ZnO 和 TiCT 相比，所制备的 ZnO/TiCT 具有更好的光热能力。局部热效应不仅可以破坏细菌膜的完整性，还可以促进 Zn 离子的释放，从而进一步提高抗菌性能。在 150 μg mL 时，ZnO/TiCT 达到了 100%的杀菌率（优于 ZnO 或 TiCT）。生物膜消解实验进一步证明了其优异的生物膜消融效果。更重要的是，细胞培养和动物实验的结果证明了其良好的生物安全性。综上所述，这种新型纳米材料表现出强烈的局部化学光热杀菌能力，具有替代传统抗菌剂的巨大潜力。
