芳基酮的串联合成通过芳基硼酸与醛的邻位铂化三芳基亚膦酸盐催化加成反应，然后进行氧化反应。
Aryl ketone synthesis via tandem orthoplatinated triarylphosphite-catalyzed addition reactions of arylboronic acids with aldehydes followed by oxidation.
机构信息
Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, New York 10314, USA.
出版信息
J Org Chem. 2010 Oct 15;75(20):6986-9. doi: 10.1021/jo101469s.
Abstract
Tandem orthoplatinated triaryl phosphite-catalyzed addition reactions of arylboronic acids with aldehydes followed by oxidation to yield aryl ketones is described. 3-Pentanone was identified as a suitable oxidant for the tandem aryl ketone formation reaction. By using microwave energy, aryl ketones were obtained in high yields with the catalyst loading as low as 0.01%.
摘要
描述了偕二正膦酸三芳基酯催化的芳基硼酸与醛的加成反应，然后氧化得到芳基酮。已鉴定出 3-戊酮是适合用于串联芳基酮形成反应的氧化剂。通过使用微波能量，即使催化剂负载量低至 0.01%，也可以高产率获得芳基酮。
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