College of Horticulture, Hainan University, Haikou 570228, China.
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products, Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou 571101, China.
J Asian Nat Prod Res. 2021 Nov;23(11):1030-1036. doi: 10.1080/10286020.2020.1849150. Epub 2020 Nov 23.
Two new compounds named epipaxilline () and penerpene J () were isolated from the marine-derived fungus sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds and showed inhibitory activities against PTP1B with IC values of 31.5 and 9.5 μM, respectively, and compound also showed inhibitory activities against TCPTP with IC value of 14.7 μM.
从海洋来源的真菌 sp. KFD28 中分离得到两个新化合物，命名为 epipaxilline () 和 penerpene J ()。基于光谱方法和 ECD 分析确定了它们的结构包括绝对构型。化合物 和 对 PTP1B 表现出抑制活性，IC 值分别为 31.5 和 9.5 μM，化合物 对 TCPTP 也表现出抑制活性，IC 值为 14.7 μM。
