Chari Divya A, Madhani Amsal, Sharon Jeffrey D, Lewis Richard F
Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Otolaryngology - Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA, USA.
J Neurol. 2022 Nov;269(11):5831-5842. doi: 10.1007/s00415-022-11289-3. Epub 2022 Aug 5.
Extensive animal research has shown that vestibular damage can be associated with cognitive deficits. More recently, new evidence has emerged linking vestibular disorders to cognitive impairment in humans. Herein, we review contemporary research on the pathophysiology of cognitive-vestibular interactions and discuss its emerging clinical relevance.
PubMed, Embase, and Cochrane databases.
A systematic literature search was performed with combinations of search terms: "cognition," "cognitive impairment," "chronic fatigue," "brain fog," "spatial navigation," "attention," "memory," "executive function," "processing speed," and "vestibular hypofunction." Relevant articles were considered for inclusion, including basic and clinical studies, case series, and major reviews.
Patients with vestibular disorders can demonstrate long-term deficits in both spatial and nonspatial cognitive domains. The underlying mechanism(s) linking the vestibular system to cognitive function is not well characterized, but several neuro-biologic correlates have been identified. Additional screening tools are required to identify individuals at risk for cognitive impairment, and further research is needed to determine whether treatment of vestibular dysfunction has the capacity to improve cognitive function.
Physicians should be aware of emerging data supporting the presence of cognitive deficits in patients with vestibular disorders. Prevention and treatment of long-term cognitive deficits may be possible through screening and rehabilitation.
大量动物研究表明，前庭损伤可能与认知缺陷有关。最近，有新证据表明前庭疾病与人类认知障碍有关。在此，我们综述了关于认知 - 前庭相互作用病理生理学的当代研究，并讨论其新出现的临床意义。
PubMed、Embase和Cochrane数据库。
使用以下搜索词组合进行系统的文献检索：“认知”、“认知障碍”、“慢性疲劳”、“脑雾”、“空间导航”、“注意力”、“记忆”、“执行功能”、“处理速度”和“前庭功能减退”。纳入相关文章，包括基础和临床研究、病例系列以及主要综述。
前庭疾病患者在空间和非空间认知领域均可出现长期缺陷。将前庭系统与认知功能联系起来的潜在机制尚未完全明确，但已确定了一些神经生物学关联。需要更多的筛查工具来识别有认知障碍风险的个体，还需要进一步研究以确定前庭功能障碍的治疗是否能够改善认知功能。
医生应了解支持前庭疾病患者存在认知缺陷的新数据。通过筛查和康复可能预防和治疗长期认知缺陷。
