Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Cell Stem Cell. 2022 Aug 4;29(8):1161-1180. doi: 10.1016/j.stem.2022.07.006.
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis. However, the mechanisms by which they contribute to both physiologic and pathologic states of extracellular matrix deposition and remodeling are just starting to be understood. In this review article, we discuss the current state of knowledge in fibroblast biology and heterogeneity, with a primary focus on the role of fibroblasts in skin wound repair. We also consider emerging techniques in the field, which enable an increasingly nuanced and contextualized understanding of these complex systems, and evaluate limitations of existing methodologies and knowledge. Collectively, this review spotlights a diverse body of research examining an often-overlooked cell type-the fibroblast-and its critical functions in wound repair and beyond.
成纤维细胞是一种高度动态的细胞，在组织修复和纤维化中起着核心作用。然而，它们在细胞外基质沉积和重塑的生理和病理状态中发挥作用的机制才刚刚开始被理解。在这篇综述文章中，我们讨论了成纤维细胞生物学和异质性的现有知识状态，主要关注成纤维细胞在皮肤伤口修复中的作用。我们还考虑了该领域新兴的技术，这些技术使我们能够越来越细致和有背景地理解这些复杂系统，并评估现有方法和知识的局限性。总的来说，这篇综述突出了大量研究，这些研究检查了一种经常被忽视的细胞类型——成纤维细胞及其在伤口修复和其他方面的关键功能。
