Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, United States.
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, United States; Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, PR China.
Adv Drug Deliv Rev. 2022 Oct;189:114479. doi: 10.1016/j.addr.2022.114479. Epub 2022 Aug 3.
Phototherapy is a noninvasive cancer treatment that relies on the interaction between light and photoactive agents. These photoactive agents are typically organic dyes, but their hydrophobic nature and self-aggregation tendency in biological media greatly restricts the development of highly effective phototherapeutic systems. In the past decade, functional dye-doped metal-organic framework (MOF)-based phototherapy has attracted enormous interest because organic dyes can be encapsulated and isolated within the MOF structure to show superior treatment efficacy. In addition to incorporating the reported phototherapeutic dyes into MOF as the ligand or the guest in the pores, the construction of an MOF-based phototherapy agent can also be extended to these dye units that are previously inactive for phototherapy. Thus, this review focuses on the emerging development of phototherapeutic MOFs that exhibited better performance than the involving dye units due to the controlled dye aggregation within the MOF. The related mechanisms and some emerging future directions of dye-doped MOF-based phototherapy are also discussed and summarized.
光疗是一种非侵入性的癌症治疗方法，依赖于光和光活性试剂之间的相互作用。这些光活性试剂通常是有机染料，但它们在生物介质中的疏水性和自聚集倾向极大地限制了高效光疗系统的发展。在过去的十年中，基于功能染料掺杂的金属有机骨架（MOF）的光疗引起了极大的兴趣，因为有机染料可以被封装和隔离在 MOF 结构中，以显示出优异的治疗效果。除了将报道的光疗染料作为配体或孔中的客体掺入 MOF 中外，MOF 基光疗剂的构建还可以扩展到这些先前对光疗没有活性的染料单元。因此，本综述重点介绍了由于 MOF 内控制的染料聚集，表现出比涉及的染料单元更好性能的光疗 MOF 的新兴发展。还讨论和总结了掺杂染料的 MOF 基光疗的相关机制和一些新兴的未来方向。
