Department of Reproductive Medicine Center, Renmin Hospital, Wuhan University, Zhangzhidong Road (formerly Ziyang Road), Wuchang District, Wuhan, 430060, China.
Department of Healthcare Management, School of Health Sciences, Wuhan University, 115 Donghu Road, Wuchang District, Wuhan, 430071, China.
Environ Health. 2020 Apr 28;19(1):44. doi: 10.1186/s12940-020-00595-w.
Few epidemiological investigations have focused on the influence of environmental temperature on human sperm quality. Here, we evaluated the potential association between ambient temperature and human sperm quality in Wuhan, China, and examined the interactive effect of particulate matter (PM) and temperature.
1780 males who had been living in Wuhan for no less than three months and received semen analysis at the Department of Reproductive Medicine in Renmin Hospital of Wuhan University between April 8, 2013 and June 30, 2015 were recruited. Daily mean meteorological data and air pollution data (PM, O and NO) in Wuhan between 2013 and 2015 were collected. A generalized linear model was used to explore the associations between ambient temperature and sperm quality (including sperm concentration, percentage of normal sperm morphology, and progressive motility) at 0-9, 10-14, 15-69, 70-90, and 0-90 days before semen examination, and the interaction between temperature and PM.
The associations between ambient temperature and sperm quality were an inverted U-shape at five exposure windows, except for a lag of 0-9 days for sperm concentration. A 1 °C increase in ambient temperature above the thresholds was associated with a 2.038 (1.292 ~ 2.783), 1.814 (1.217 ~ 2.411), 1.458 (1.138 ~ 1.777), 0.934(0.617 ~ 1.251) and 1.604 (1.258 ~ 1.951) decrease in the percentage of normal sperm morphology at lag 0-9, lag 10-14, lag 15-69, lag 70-90, and lag 0-90 days, respectively. The interaction p-values of PM and temperature were mostly less than 0.05 at five exposure windows. When ambient temperature exposure levels were above the thresholds, a 0.979 (0.659-1.299) and 3.559 (0.251 ~ 6.867) decrease in percentage of normal sperm morphology per 1 °C increase in temperature at lag 0-90 days was observed in the PM ≤ P group and PM > P group, respectively.
Our results indicate that exposure to ambient temperature has a threshold effect on sperm quality, and PM enhances the effect of temperature on sperm quality when temperatures are above the threshold.
很少有流行病学研究关注环境温度对人类精子质量的影响。在这里，我们评估了中国武汉地区环境温度与人类精子质量之间的潜在关联，并研究了颗粒物（PM）和温度之间的交互作用。
2013 年 4 月 8 日至 2015 年 6 月 30 日，共招募了 1780 名在武汉居住不少于三个月并在武汉大学人民医院生殖医学科接受精液分析的男性。收集了 2013 年至 2015 年期间武汉每日平均气象数据和空气污染数据（PM、O 和 NO）。采用广义线性模型探讨了环境温度与精子质量（包括精子浓度、正常精子形态百分比和前向运动精子百分比）在精液检查前 0-9、10-14、15-69、70-90 和 0-90 天之间的关联，以及温度与 PM 之间的相互作用。
在五个暴露窗口中，除了精子浓度的滞后 0-9 天外，环境温度与精子质量之间的关系呈倒 U 形。与阈值以上的环境温度每升高 1°C 相关的是，精子形态正常百分比的滞后 0-9、10-14、15-69、70-90 和 0-90 天分别降低了 2.038（1.292-2.783）、1.814（1.217-2.411）、1.458（1.138-1.777）、0.934（0.617-1.251）和 1.604（1.258-1.951）。在五个暴露窗口中，PM 和温度的交互作用 p 值大多小于 0.05。当环境温度暴露水平高于阈值时，在 PM≤P 组和 PM>P 组中，滞后 0-90 天，温度每升高 1°C，正常精子形态百分比分别降低 0.979（0.659-1.299）和 3.559（0.251-6.867）。
我们的研究结果表明，环境温度对精子质量有阈值效应，当温度高于阈值时，PM 会增强温度对精子质量的影响。
