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苦参碱@壳聚糖-D-脯氨酸纳米胶囊作为海洋环境中具有抗菌性能和生物膜分散性的防污剂。

Matrine@chitosan-D-proline nanocapsules as antifouling agents with antibacterial properties and biofilm dispersibility in the marine environment.

作者信息

Hao Xiangping, Yan Weilu, Yang Jingzhi, Bai Yun, Qian Hongchang, Lou Yuntian, Ju Pengfei, Zhang Dawei

机构信息

National Materials Corrosion and Protection Data Center, Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing, China.

Belt and Road Initiative (BRI) Southeast Asia Network for Corrosion and Protection, Ministry of Education (MOE), Shunde Graduate School of University of Science and Technology Beijing, Foshan, China.

出版信息

Front Microbiol. 2022 Jul 22;13:950039. doi: 10.3389/fmicb.2022.950039. eCollection 2022.

DOI:10.3389/fmicb.2022.950039
PMID:35935227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9355532/
Abstract

Antifoulants are the most vital substances in antifouling coatings to prevent marine organisms from colonizing the undersea substrate surfaces. In addition to antibacterial performance, inhibition of biofilm formation is an important criterion for antifouling coatings. In this study, we synthesized pH-responsive matrine@chitosan-D-proline (Mat@CS-Pro) nanocapsules of about 280 nm with antibacterial properties and biofilm dispersibility. The prepared Mat@CS-Pro nanocapsules exhibited high-level antibacterial properties, reaching about 93, 88, and 96% for , and , respectively. Such nanocapsules can cause irreversible damage to bacteria and cause them to lose their intact cell structures. Moreover, Mat@CS-Pro nanocapsules also possessed outstanding dispersal biofilm performances, in which the biofilm thickness of , and was decreased by 33, 74, and 42%, respectively, after 3 days of incubation. Besides, the Mat@CS-Pro nanocapsules had remarkable pH-responsive properties. As the environmental pH became acidic, the nanocapsules swelled to about 475 nm and the released concentration could reach 28.5 ppm after immersion for 10 h but maintained a low releasing rate in pH 8 conditions.

摘要

防污剂是防污涂料中最重要的物质，可防止海洋生物在海底基质表面定殖。除抗菌性能外，抑制生物膜形成是防污涂料的一个重要标准。在本研究中，我们合成了具有抗菌性能和生物膜分散性的约280 nm的pH响应型苦参碱@壳聚糖-D-脯氨酸（Mat@CS-Pro）纳米胶囊。制备的Mat@CS-Pro纳米胶囊表现出高水平的抗菌性能，对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的抗菌率分别达到约93%、88%和96%。这种纳米胶囊可对细菌造成不可逆损伤，使其失去完整的细胞结构。此外，Mat@CS-Pro纳米胶囊还具有出色的生物膜分散性能，孵育3天后，金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的生物膜厚度分别降低了33%、74%和42%。此外，Mat@CS-Pro纳米胶囊具有显著的pH响应特性。随着环境pH值变酸，纳米胶囊膨胀至约475 nm，浸泡10 h后释放浓度可达28.5 ppm，但在pH 8条件下释放速率较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74a/9355532/f5627796b34e/fmicb-13-950039-g0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74a/9355532/ef34b691ce28/fmicb-13-950039-g0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74a/9355532/84a1bdc50a8e/fmicb-13-950039-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74a/9355532/2a4f54ee6aa0/fmicb-13-950039-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74a/9355532/223bb89cac95/fmicb-13-950039-g0007.jpg
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