Department of Spine Surgery, The First Affiliated Hospital of Anhui Medical University, HeFei 230022, Anhui, China.
Contrast Media Mol Imaging. 2022 Jul 19;2022:5960317. doi: 10.1155/2022/5960317. eCollection 2022.
The aim of this study is to study the relationship between the degree of lumbar disc degeneration and the height of the disc in patients with pain in the lower back and determine whether there is a dose-response relationship between the two. Eighty-five patients were examined by magnetic resonance imaging (MRI). The grade of lumbar degeneration was determined by the Pfirrmann grading system, and the intervertebral height and VAS pain scores were measured. The height difference of intervertebral discs with different degeneration levels was measured by the F test. This difference was correlated and further quantified by regression analysis. Finally, the differences intervertebral disc heights with a VAS score of 0-6 and 7-10 were observed by an independent sample -test. The higher degree of disc degeneration in each lumbosacral segment, the lower the intervertebral disc height ( ≤ 0.011). When discs with grade 1 and grade 5 degeneration were excluded, the results remained the same ( ≤ 0.034). To quantify correlations, at each lumbar level, the disc height was reduced for each level of lumbosacral disc degeneration, and the height of disc was reduced after adjusting according to age, sex, and BMI ( range: -1.25 mm to -1.76 mm, 95% CI: -0.83 to -2.29, all ≤ 0.002). Subjects with a VAS score of 7-10 had a lower intervertebral disc height than those with a VAS score of 0-6, especially with respect to total height levels at L4/5, L5/S1, and L1-S1 ( ≤ 0.04). This study showed a relationship between increased degree of intervertebral disc degeneration and decreased the disc height in patients with pain in the low back. Although the assessment of lumbar and lumbosacral level disc degeneration involves many qualitative measurements, these statistical data confirm the effectiveness of lumbosacral disc height as a continuous data measure and quantification in clinical trials and epidemiological studies.
本研究旨在探讨腰痛患者腰椎间盘退变程度与椎间盘高度的关系，并确定两者之间是否存在剂量-反应关系。对 85 例患者进行磁共振成像（MRI）检查。采用 Pfirrmann 分级系统确定腰椎退变程度，测量椎间盘高度和视觉模拟评分（VAS）疼痛评分。采用 F 检验测量不同退变水平椎间盘的高度差。通过回归分析对这种差异进行相关性和进一步量化。最后，通过独立样本 t 检验观察 VAS 评分为 0-6 和 7-10 的椎间盘高度差异。每个腰骶段椎间盘退变程度越高，椎间盘高度越低（≤0.011）。当排除 1 级和 5 级退变的椎间盘时，结果仍然相同（≤0.034）。为了量化相关性，在每个腰椎水平，根据腰骶段椎间盘退变程度每增加一级，调整年龄、性别和 BMI 后，椎间盘高度降低（范围：-1.25mm 至-1.76mm，95%CI：-0.83 至-2.29，均≤0.002）。VAS 评分为 7-10 的患者的椎间盘高度低于 VAS 评分为 0-6 的患者，尤其是 L4/5、L5/S1 和 L1-S1 的总高度水平（≤0.04）。本研究表明腰痛患者椎间盘退变程度增加与椎间盘高度降低之间存在相关性。尽管评估腰椎和腰骶段椎间盘退变涉及许多定性测量，但这些统计数据证实了腰椎和腰骶段椎间盘高度作为临床试验和流行病学研究中连续数据测量和量化的有效性。
