El Mehdi Iouraouine, Falcão Soraia I, Boujraf Saïd, Mustapha Harandou, Campos Maria G, Vilas-Boas Miguel
Prof. Said, Clinical Neurosciences Laboratory, Faculty of Medicine and Pharmacy; Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.
Department of Biophysics and Clinical MRI Methods, Faculty of Medicine and Pharmacy, University Sidi Mohamed ben Abdellah, Fez, Morocco.
J Adv Pharm Technol Res. 2022 Jul-Sep;13(3):154-160. doi: 10.4103/japtr.japtr_166_21. Epub 2022 Jul 5.
The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti-inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS-CoV-2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV-derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation.
毒液组学研究的发展极大地促进了新药的发现，增进了我们对中毒过程的理解。此前有报道称，蜜蜂毒液（HBV）具有多种药理活性，如抗炎、抗菌、抗诱变、辐射防护和抗癌活性，可能还可作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的辅助治疗方法。其成分主要包括蜂毒肽、磷脂酶A2和蜂毒明肽，但其他成分如透明质酸酶、肥大细胞脱颗粒肽和secapin对其生物活性也很重要。然而，由于HBV尚未被官方认定为药物，到目前为止，国际社会尚未为其制定质量标准。为了揭示其确切成分，并推动基于HBV的药物发现，人们开发了大量技术。在这篇综述中，对迄今为止发表的用于HBV表征的分析方法进行了相关概述，旨在加速其未来的标准化进程。通过在PubMed、谷歌学术和科学Direct中选择特定文档并探索HBV评估来进行文献检索。
