Department of palliative care, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; Research Center for Palliative Care, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu 610041, China.
Emergency Department, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Int J Biol Macromol. 2022 May 31;208:400-408. doi: 10.1016/j.ijbiomac.2022.03.002. Epub 2022 Mar 3.
Human understanding of skin is constantly ongoing. Great progress has been made in skin repair, wound dressing regeneration biomaterials research in recent years. This review introduced the clinical research and guiding principles of skin repair, wound dressing biomaterials at home and abroad, introduced the classification of various skin repair and wound dressing, listed the composition and performance of different dressing biomaterials, including traditional, natural, synthetic, tissue-engineered dressing materials were extensively reviewed. The biological molecular structures and biological function characteristics of different dressing biomaterials are comprehensively reviewed. Collagen, chitosan, alginate hydrogels et al. as the most popular biological macromolecules in skin repair and wound dressing applications were reviewed. The future development direction is also prospected. This paper reviews the research progress of advanced functional skin repair and wound dressing, which provides a reference for the modifications and applications of wound dressings.
人类对皮肤的认识一直在不断深入。近年来，皮肤修复、创面敷料再生生物材料的研究取得了重大进展。本综述介绍了国内外皮肤修复、创面敷料生物材料的临床研究和指导原则，介绍了各种皮肤修复和创面敷料的分类，列出了不同敷料生物材料的组成和性能，包括传统、天然、合成、组织工程敷料材料都得到了广泛的回顾。全面综述了不同敷料生物材料的生物分子结构和生物学功能特性。胶原蛋白、壳聚糖、海藻酸盐水凝胶等作为皮肤修复和创面敷料应用中最受欢迎的生物大分子进行了综述。展望了未来的发展方向。本文综述了先进功能性皮肤修复和创面敷料的研究进展，为创面敷料的修饰和应用提供了参考。
