Vico L, Chappard D, Alexandre C, Palle S, Minaire P, Riffat G, Novikov V E, Bakulin A V
Bone. 1987;8(2):95-103. doi: 10.1016/8756-3282(87)90077-9.
Five pregnant growing rats were orbited for 5 days aboard the Soviet COSMOS 1514 biologic satellite. The bone effects of weightlessness were studied and compared to those of five pregnant rats kept in vivarium and five pregnant conditioned rats. Bone histomorphometric studies were performed to investigate the early effects of weightlessness in loaded (tibia-femur) and unloaded (thoracic and lumbar vertebrae) bones. A short exposure to weightlessness does not induce any change in bone mass and inner structure in either type of bone. In unloaded bones, the number of osteoclasts per square millimeter of the trabecular surface significantly increased when measured after histochemical demonstration of tartrate-resistant acid phosphatase. It is likely that a stimulation of bone resorption activity occurs in the trabeculae of unloaded bones during the early phase of a spaceflight. In tibia, osteoid seam thickness and total osteoclastic resorption surfaces at the endosteal level were not modified.
五只怀孕的成年大鼠搭乘苏联的宇宙1514生物卫星进行了5天的轨道飞行。研究了失重对骨骼的影响，并与饲养在动物饲养室的五只怀孕大鼠和五只怀孕的对照大鼠进行了比较。进行了骨组织形态计量学研究，以调查失重对负重骨骼（胫腓骨）和非负重骨骼（胸椎和腰椎）的早期影响。短期暴露于失重环境不会导致任何一种类型的骨骼在骨量和内部结构上发生变化。在非负重骨骼中，经抗酒石酸酸性磷酸酶组织化学显示后测量，每平方毫米小梁表面的破骨细胞数量显著增加。在太空飞行的早期阶段，非负重骨骼的小梁中可能会发生骨吸收活动的刺激。在胫骨中，骨内膜水平的类骨质缝厚度和总破骨细胞吸收表面没有改变。
