Kabi Arup K, Pal Maynak, Gujjarappa Raghuram, Malakar Chandi C, Roy Mithun
Department of Chemistry National Institute of Technology Manipur Imphal Manipur India.
J Heterocycl Chem. 2022 Jul 28. doi: 10.1002/jhet.4541.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the ongoing pandemic named COVID-19 which causes a serious emergency on public health hazards of international concern. In the face of a critical medical emergency, repositioning of drugs is one of the most authentic options to design an adequate treatment for infected patients immediately. In this strategy, Remdesivir (Veklury), Hydroxychloroquine appears to be the drug of choice and garnered unprecedented attention as potential therapeutic agents against the pandemic realized worldwide due to SARS-CoV-2 infection. These are the breathtaking instances of possible repositioning of drugs, whose pharmacokinetics and optimal dosage are familiar. In this review, we provide an overview of these medications, their synthesis, and the possible mechanism of action against SARS-CoV-2.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了正在肆虐的大流行，即2019冠状病毒病（COVID-19），这在国际关注的突发公共卫生事件中引发了严重危机。面对这一危急的医疗紧急情况，药物重新定位是立即为感染患者设计适当治疗方案的最可靠选择之一。在这一策略中，瑞德西韦（Veklury）、羟氯喹似乎是首选药物，并作为针对由SARS-CoV-2感染导致的全球大流行的潜在治疗药物获得了前所未有的关注。这些是药物可能重新定位的惊人实例，其药代动力学和最佳剂量是已知的。在本综述中，我们概述了这些药物、它们的合成以及针对SARS-CoV-2的可能作用机制。
