Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, Illinois, USA.
Arch Iran Med. 2022 May 1;25(5):279-284. doi: 10.34172/aim.2022.46.
Disruptions in sleep related to mealtime may contribute to gut microbial imbalances, and put individuals at higher risk for metabolic diseases. The aim of this pilot study was to investigate the relationships between late-night eating habits and sleep quality and duration, with gut microbiota (GM) profiles.
In this cross-sectional study, 36 men referred to a clinic were enrolled. In addition to demographic information, each participant completed questionnaires regarding medical history, physical activity, late-night eating habits, sleep quality and sleep duration. The scores from these questionnaires were used to categorize study participants into the following groups: sleep quality (good or poor), late-night eating (yes or no) and sleep duration (<7 or ≥7 hours). Five grams of stool was also obtained from each participant for GM profiling analysis by sequencing.
The mean age of the study population was 42.1 ± 1.6 years. and were the two dominant phyla present in all participant samples. Differences in the relative abundance of GM at each taxonomic rank between study groups were insignificant. Only at the order level were found to be significantly different between individuals who had late-night eating habits and those who did not ( & < 0.05). No other parameter demonstrated a significant difference in GM profiles of participants.
In this pilot study, we found to be more abundant in individuals with late-night eating habits. Studies with higher sample sizes are warranted to better delineate the possible effects of time of eating on microbial composition.
与进餐相关的睡眠中断可能导致肠道微生物失衡，使个体患代谢性疾病的风险更高。本研究旨在探讨夜间进食习惯与睡眠质量和时长与肠道微生物群（GM）之间的关系。
在这项横断面研究中，招募了 36 名男性。除了人口统计学信息外，每位参与者还完成了关于病史、身体活动、夜间进食习惯、睡眠质量和睡眠时间的问卷。这些问卷的得分用于将研究参与者分为以下组：睡眠质量（好或差）、夜间进食（是或否）和睡眠时间（<7 或≥7 小时）。还从每位参与者中获取 5 克粪便，通过测序进行 GM 分析。
研究人群的平均年龄为 42.1 ± 1.6 岁。在所有参与者样本中，和是存在的两个主要菌群。各组间 GM 在分类等级上的相对丰度差异无统计学意义。仅在目水平上发现有夜间进食习惯的个体与没有夜间进食习惯的个体之间存在显著差异（& < 0.05）。其他参数在 GM 图谱方面没有表现出参与者之间的显著差异。
在这项初步研究中，我们发现夜间进食习惯的个体中丰度更高。需要更大样本量的研究来更好地阐明进食时间对微生物组成的可能影响。
