槲皮素补充对血压的影响 - 荟萃分析。

The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis.

机构信息

Department of Bioanalytics, Medical University of Lublin, Lublin, Poland; Department of Cardiology, Cardinal Wyszynski Hospital in Lublin, Lublin, Poland.

Department of Bioanalytics, Medical University of Lublin, Lublin, Poland.

出版信息

Curr Probl Cardiol. 2022 Nov;47(11):101350. doi: 10.1016/j.cpcardiol.2022.101350. Epub 2022 Aug 7.

DOI:10.1016/j.cpcardiol.2022.101350

PMID:35948195

Abstract

The effects of quercetin supplementation on blood pressure (BP) remain unclear. The aim of this meta-analysis is to summarize data focused on quercetin impact on systolic BP (SBP) and diastolic BP (DBP). Medline, EMBASE and Web of Science databases were searched to identify randomized controlled trials that assessed the impact of quercetin on BP until May 2022. A random-effects model was used for data analysis. Subgroup analysis was performed to explore the effects in (pre)hypertensive and normotensive adults. Ten trials (841 participants in total) were included into the analysis. The results showed that quercetin supplementation significantly decreased SBP in the mixed population (MD: -2.38mmHg; 95% CI: -3.80 - -0.96; P = 0.01) and in the normotensive subgroup (MD: -1.82mmHg; 95% CI: -2.43 - -1.20; P < 0.0001) and DBP in the (pre)hypertensive subgroup (MD: -3.14mmHg; 95% CI: -4.44 - -1.84; P < 0.00001). Quercetin supplementation decreases BP in normotensive and (pre)hypertensive patients.

摘要

槲皮素补充剂对血压（BP）的影响尚不清楚。本荟萃分析的目的是总结集中研究槲皮素对收缩压（SBP）和舒张压（DBP）影响的数据。检索了 Medline、EMBASE 和 Web of Science 数据库，以确定评估槲皮素对 BP 影响的随机对照试验，截至 2022 年 5 月。采用随机效应模型进行数据分析。进行亚组分析以探讨（前期）高血压和正常血压成年人中的影响。共有 10 项试验（总计 841 名参与者）纳入分析。结果表明，槲皮素补充剂在混合人群中显著降低了 SBP（MD：-2.38mmHg；95%CI：-3.80- -0.96；P=0.01）和正常血压亚组（MD：-1.82mmHg；95%CI：-2.43- -1.20；P<0.0001）以及（前期）高血压亚组的 DBP（MD：-3.14mmHg；95%CI：-4.44- -1.84；P<0.00001）。槲皮素补充剂可降低正常血压和（前期）高血压患者的 BP。