Department of Emergency, Xuancheng People's Hospital, Xuancheng, China.
Department of Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
J Clin Lab Anal. 2022 Sep;36(9):e24564. doi: 10.1002/jcla.24564. Epub 2022 Aug 10.
To investigate the effect of artificial skin on the expression of miR-155 and miR-506-3p in patients with second-degree burns.
The study subjects included 50 patients with second-degree burns treated from July 2019 to July 2021. The control group received routine nursing, while the research group received both routine and artificial skin intervention simultaneously. The changes in wound tissue fibrosis and prognosis were observed. The expression levels of miR-155 and miR-506-3p and their downstream regulatory factors were detected and correlated with the rehabilitation of patients after artificial skin treatment.
After treating second-degree burns with artificial skin membranes, the patient's wound tissue fibrosis and inflammation level improved. At the same time, the expression levels of miR-155 and miR-506-3p in related tests were higher than those in patients with available treatment.
The effect of artificial skin membrane on the wound healing of second-degree burn patients may be realized by influencing the expression levels of miR-155 and miR-506-3p and their related signaling pathways.
研究人工皮肤对二度烧伤患者 miR-155 和 miR-506-3p 表达的影响。
本研究选取 2019 年 7 月至 2021 年 7 月收治的 50 例二度烧伤患者作为研究对象。对照组给予常规护理，研究组在常规护理的基础上联合应用人工皮肤干预。观察两组患者创面组织纤维化和预后变化，检测 miR-155 和 miR-506-3p 及其下游调控因子的表达水平，并与人工皮肤治疗后患者康复情况进行相关性分析。
应用人工皮肤膜治疗二度烧伤后，患者创面组织纤维化和炎症水平得到改善，相关检测中 miR-155 和 miR-506-3p 的表达水平高于常规治疗组。
人工皮肤膜对二度烧伤患者创面愈合的影响可能是通过影响 miR-155 和 miR-506-3p 及其相关信号通路的表达水平来实现的。
