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Combination Immunotherapy with Anti-PD-1/PD-L1 Antibody plus Anti-VEGF Antibody May Promote Cytotoxic T Lymphocyte Infiltration in Hepatocellular Carcinoma, Including in the Noninflamed Subclass.

作者信息

Kudo Masatoshi

机构信息

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.

出版信息

Liver Cancer. 2022 May 10;11(3):185-191. doi: 10.1159/000524977. eCollection 2022 Jun.

DOI:10.1159/000524977
PMID:35949296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9218634/
Abstract
摘要

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Gut. 2023 Jan;72(1):129-140. doi: 10.1136/gutjnl-2021-325918. Epub 2022 Feb 23.
2
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Cancers (Basel). 2022 Jan 17;14(2):444. doi: 10.3390/cancers14020444.
3
Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1 and immune desert‑like mouse tumors.抗血管内皮生长因子抗体触发 PD-L1 和免疫荒漠样小鼠肿瘤中抗 PD-L1 抗体的作用。
Oncol Rep. 2022 Feb;47(2). doi: 10.3892/or.2021.8247. Epub 2021 Dec 27.
4
Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma.钆塞酸二钠增强MRI肝胆期肝内结节强化程度较高作为不可切除肝细胞癌抗PD-1/PD-L1单药治疗反应不佳的标志物
Liver Cancer. 2021 Aug 19;10(6):615-628. doi: 10.1159/000518048. eCollection 2021 Nov.
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Liver Cancer. 2021 Oct 12;10(6):539-544. doi: 10.1159/000519749. eCollection 2021 Nov.
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Immunological Microenvironment Predicts the Survival of the Patients with Hepatocellular Carcinoma Treated with Anti-PD-1 Antibody.免疫微环境可预测接受抗PD-1抗体治疗的肝细胞癌患者的生存情况。
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Anti-angiogenic agents - overcoming tumour endothelial cell anergy and improving immunotherapy outcomes.抗血管生成药物——克服肿瘤内皮细胞不应答和改善免疫治疗效果。
Nat Rev Clin Oncol. 2021 Aug;18(8):527-540. doi: 10.1038/s41571-021-00496-y. Epub 2021 Apr 8.