Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas.
J Appl Physiol (1985). 2022 Sep 1;133(3):742-754. doi: 10.1152/japplphysiol.00181.2022. Epub 2022 Aug 11.
Exercise training reduces cardiovascular disease risk, partly due to arterial blood pressure (BP) lowering at rest and during fixed-load exercise. However, it is unclear whether exercise training can reduce BP at rest and during exercise in adults with well-healed burn injuries. Therefore, the purpose of this investigation was to test the hypothesis that 6 mo of unsupervised exercise training reduces BP at rest and during lower-body cycle ergometry in adults with well-healed burn injuries. Thirty-nine adults (28 with well-healed burn injuries and 11 controls) completed 6 mo of unsupervised, progressive exercise training including endurance, resistance, and high-intensity interval components. Before and after exercise training, we measured BP at rest, during fixed-load submaximal exercise (50 and 75 W), during fixed-intensity submaximal exercise (40% and 70% of V̇o), and during maximal exercise on a lower-body cycle ergometer. We compared cardiovascular variables using two-way ANOVA (group × pre/postexercise training [repeated factor]). Adults with well-healed burn injuries had higher diastolic BP at rest ( = 0.04), which was unchanged by exercise training ( = 0.26). Exercise training reduced systolic, mean, and diastolic BP during fixed-load cycling exercise at 75 W in adults with well-healed burn injuries ( ≤ 0.03 for all), but not controls ( ≥ 0.67 for all). Exercise training also reduced mean and diastolic BP during exercise at 40% ( ≤ 0.02 for both), but not at 70% ( ≥ 0.18 for both), of V̇o. These data suggest that a 6-mo unsupervised exercise training program lowers BP during moderate, but not vigorous, aerobic exercise in adults with well-healed burn injuries. Adults with well-healed burn injuries have greater cardiovascular disease morbidity and all-cause mortality compared with nonburn-injured adults. We found that exercise training reduced blood pressure (BP) during fixed-load cycling at 75 W and during moderate, but not vigorous, intensity cycling exercise in adults with well-healed burn injuries. These data suggest that 6 mo of unsupervised exercise training provides some degree of cardioprotection by reducing BP responses during submaximal exercise in well-healed burn-injured adults.
运动训练可降低心血管疾病风险，部分原因是其能降低静息和固定负荷运动时的动脉血压（BP）。然而，目前尚不清楚运动训练是否可以降低愈合良好的烧伤患者的静息和运动时的 BP。因此，本研究旨在检验以下假设：6 个月的非监督运动训练可降低愈合良好的烧伤患者静息和下肢踏车运动时的 BP。39 名成年人（28 名愈合良好的烧伤患者和 11 名对照）完成了 6 个月的非监督、渐进性运动训练，包括耐力、阻力和高强度间歇成分。在运动训练前后，我们测量了静息时、固定负荷亚极量运动（50 和 75 W）时、固定强度亚极量运动（40%和 70%VO2max）时以及下肢踏车运动时的 BP。我们使用双因素方差分析（组×运动前后[重复因素]）比较了心血管变量。愈合良好的烧伤患者静息时舒张压较高（P=0.04），运动训练后无变化（P=0.26）。运动训练降低了愈合良好的烧伤患者固定负荷踏车运动 75 W 时的收缩压、平均压和舒张压（P≤0.03），但对对照组无影响（P≥0.67）。运动训练还降低了愈合良好的烧伤患者运动时的平均压和舒张压（P≤0.02），但对对照组无影响（P≥0.18）。这些数据表明，6 个月的非监督运动训练可降低愈合良好的烧伤患者中等到剧烈有氧运动时的 BP。与非烧伤成年人相比，愈合良好的烧伤患者患心血管疾病的发病率和全因死亡率更高。我们发现，运动训练降低了愈合良好的烧伤患者固定负荷踏车运动 75 W 时和中等强度踏车运动时的血压（BP）。这些数据表明，6 个月的非监督运动训练可降低愈合良好的烧伤患者亚极量运动时的 BP 反应，从而提供一定程度的心脏保护作用。
