Missier Mary Sheloni, Ramakrishnan Mahesh, Veerasankar S, Dhanalakshmi C, Ponniah Harish, Rajeshkumar Shanmugam
Department of Orthodontics, Saveetha Dental College and Hospital, SIMATS, Saveetha University, Chennai, Tamil Nadu, India.
Department of Pedodontics,Saveetha Dental College and Hospital, SIMATS, Saveetha University, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2024 Dec;16(Suppl 5):S4421-S4425. doi: 10.4103/jpbs.jpbs_854_24. Epub 2025 Jan 30.
The emergence of antibiotic-resistant pathogenic bacteria has become a major global health concern, with the increasing prevalence of infections that are difficult to treat with conventional antibiotics. As a result, there is a critical need for alternative antimicrobial agents that can effectively control bacterial infections and combat the growing problem of antibiotic resistance.
In this study, the antibacterial properties of lemon juice mediated zinc oxide nanoparticles (ZnO NPs) and titanium dioxide nanoparticles (TiO2 NPs) was evaluated against oral pathogens. The synthesized nanoparticles were characterized using UV-Vis spectroscopy. The antimicrobial activity of the nanoparticles was determined by the agar well diffusion assay.
Our results showed that both ZnO NPs and TiO2 NPs exhibited potent antimicrobial activity against both and . Our findings suggest that the antimicrobial activity of ZnO NPs and TiO2 NPs is attributed to the disruption of bacterial cell membrane integrity and inhibition of bacterial growth.
Therefore, lemon juice mediated ZnO NPs and TiO2 NPs can be considered as promising antimicrobial agents for controlling bacterial infections.
抗生素耐药性病原菌的出现已成为全球主要的健康问题，常规抗生素难以治疗的感染患病率不断上升。因此，迫切需要能够有效控制细菌感染并应对日益严重的抗生素耐药性问题的替代抗菌剂。
在本研究中，评估了柠檬汁介导的氧化锌纳米颗粒（ZnO NPs）和二氧化钛纳米颗粒（TiO2 NPs）对口腔病原体的抗菌性能。使用紫外可见光谱对合成的纳米颗粒进行表征。通过琼脂孔扩散试验测定纳米颗粒的抗菌活性。
我们的结果表明，ZnO NPs和TiO2 NPs对[此处原文缺失两种细菌名称]均表现出强大的抗菌活性。我们的研究结果表明，ZnO NPs和TiO2 NPs的抗菌活性归因于细菌细胞膜完整性的破坏和细菌生长的抑制。
因此，柠檬汁介导的ZnO NPs和TiO2 NPs可被视为控制细菌感染的有前景的抗菌剂。
