Zhang Shujian, Zhang Xiaohan, Huang Jie, Zhou Na, Zhang Fangping, Ren Junyu, Zhang Wenxuan, Wang Tuo, Xu Wenxia, Luan Xinrui, Huang Xiaowei, Huang Zansheng, Wu Jiaming, Da Junlong, Liu Lixue, Zhang Bin, Li Ying, Jin Han
Heilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China.
Mater Today Bio. 2025 Jul 9;33:102073. doi: 10.1016/j.mtbio.2025.102073. eCollection 2025 Aug.
Periodontitis, a multifaceted chronic inflammatory disorder affecting the oral cavity, with its etiology intricately linked to oxidative stress. Existing pharmacotherapies for periodontitis often suffer from a lack of target specificity and are challenged by the double demands of mitigating oxidative stress and promoting tissue regeneration in a coordinated, multi-pronged strategy. To address the challenges of "where" and "how", this study synthesizes both guidance and therapeutic dual logic-based Curcumin-Alendronate carbon dots (Cur-Alen CDs). Cur-Alen CDs retain the characteristics of alendronate which can accurately target periodontitis bone tissue and osteoclasts to exert guidance logic. At the same time, the therapeutic logic of Cur-Alen CDs is reflected in its superior antioxidant activity to curcumin, which effectively down-regulates the expression of key inflammatory factors and reverse the imbalance of the bone microenvironment in periodontitis. Notably, RNA sequencing of periodontitis rat models revealed that Cur-Alen CDs treat periodontitis by modulating the NF-κB signaling pathway. This study highlights the dual-logic properties of Cur-Alen CDs, namely the multi-faceted modulation of the inflammatory microenvironment and the specific targeting ability. The potential of Cur-Alen CDs for the precision therapy of periodontitis is underscored.
牙周炎是一种影响口腔的多方面慢性炎症性疾病，其病因与氧化应激密切相关。现有的牙周炎药物治疗往往缺乏靶点特异性，并且在以协调的多管齐下策略减轻氧化应激和促进组织再生的双重需求方面面临挑战。为了解决“何处”和“如何”的挑战，本研究合成了基于引导和治疗双重逻辑的姜黄素-阿仑膦酸盐碳点（Cur-Alen CDs）。Cur-Alen CDs保留了阿仑膦酸盐的特性，能够精确靶向牙周炎骨组织和破骨细胞以发挥引导逻辑。同时，Cur-Alen CDs的治疗逻辑体现在其相对于姜黄素具有更强的抗氧化活性，能有效下调关键炎症因子的表达并逆转牙周炎中骨微环境的失衡。值得注意的是，对牙周炎大鼠模型的RNA测序显示，Cur-Alen CDs通过调节NF-κB信号通路来治疗牙周炎。本研究突出了Cur-Alen CDs的双重逻辑特性，即对炎症微环境的多方面调节和特异性靶向能力。强调了Cur-Alen CDs在牙周炎精准治疗方面的潜力。
