Rantakallio P, von Wendt L, Koivu M
Early Hum Dev. 1987 Mar;15(2):75-84. doi: 10.1016/0378-3782(87)90040-5.
The prognosis of perinatal brain damage was studied prospectively in a one year birth cohort of 12,000 children born in Northern Finland in 1966. Children were included in the study if they had an Apgar score of 0 at 1 min or less than 5 at 15 min, convulsions during the neonatal period, or a diagnosis of asphyxia, brain injury or intraventricular haemorrhage, but did not have CNS malformation, chromosomal aberrations or hereditary CNS degeneration. There were 233 children, 19.3 per thousand, of which 134, 58.0% were boys. Eighty-four, 36.4% died during the first 28 days and 7 children died before the age of 14 years, 6 of the latter group being handicapped. There were 44 children, 29.9% who had mental retardation, IQ less than 71, epilepsy or cerebral palsy. With regard to these children 13 had normal school performance, but there were 12 other children in the perinatal brain damage group who needed special education, two of them because of deafness. Perinatal brain damage accounted for 57.5% of all neonatal deaths, 30% of admissions to a special nursery and 12.5% of mental retardation (IQ less than 71), epilepsy and cerebral palsy at the age of 14.
对1966年出生在芬兰北部的12000名儿童组成的一年出生队列中的围产期脑损伤预后进行了前瞻性研究。如果儿童出生后1分钟阿氏评分0分或15分钟低于5分、新生儿期惊厥、或诊断为窒息、脑损伤或脑室内出血，但无中枢神经系统畸形、染色体畸变或遗传性中枢神经系统变性，则纳入研究。共有233名儿童，占千分之19.3，其中134名（58.0%）为男孩。84名（36.4%）在出生后28天内死亡，7名儿童在14岁前死亡，后一组中有6名有残疾。有44名儿童（29.9%）有智力迟钝、智商低于71、癫痫或脑瘫。关于这些儿童，13名学业成绩正常，但围产期脑损伤组还有12名儿童需要特殊教育，其中2名是因为耳聋。围产期脑损伤占所有新生儿死亡的57.5%、特殊托儿所入院人数的30%以及14岁时智力迟钝（智商低于71）、癫痫和脑瘫的12.5%。
