Rantakallio P, von Wendt L
Acta Paediatr Scand. 1986 Jul;75(4):586-92. doi: 10.1111/j.1651-2227.1986.tb10255.x.
The one-year birth cohort from Northern Finland comprises 12 058 children, representing 96% of all live births in 1966 in the two northernmost provinces of Finland, Oulu and Lapland. Only 14 children, 1.2 per thousand, were lost during the follow-up to 14 years of age, in which data were collected prospectively on development, mortality and morbidity using questionnaires and registers. When all 47 children with cerebral palsy fulfilling the criteria of the Little Club of London (1959) were included, a prenatal risk factor was detected in 13 infants (27.7%) and a perinatal one in 25 children (53.2%), whereas 9 children (19.1%) represented an untraceable form of this disorder. There were 208 children with epilepsy, among which 18 (8.7%) had a prenatal risk factor, 38 (18.2%) a perinatal one, 33 (15.9%) a postnatal one, and 119 (57.2%) no identifiable risk factor. Among the 11 320 healthy children in the cohort alive at 14 years of age, there were 992 (8.8%) with risk factors for cerebral palsy and epilepsy. The relative risk attached to these aetiological factors was lower for epilepsy than for cerebral palsy.
来自芬兰北部的一岁出生队列包括12058名儿童，占芬兰最北部两个省份奥卢和拉普兰1966年所有活产婴儿的96%。在随访至14岁期间，仅14名儿童（千分之1.2）失访，在此期间通过问卷和登记册前瞻性收集了发育、死亡率和发病率数据。当纳入所有47名符合伦敦小儿麻痹症俱乐部（1959年）标准的脑瘫儿童时，在13名婴儿（27.7%）中检测到产前危险因素，在25名儿童（53.2%）中检测到围产期危险因素，而9名儿童（19.1%）代表这种疾病的一种无法追溯的形式。有208名癫痫儿童，其中18名（8.7%）有产前危险因素，38名（18.2%）有围产期危险因素，33名（15.9%）有产后危险因素，119名（57.2%）没有可识别的危险因素。在该队列中14岁时存活的11320名健康儿童中，有992名（8.8%）有脑瘫和癫痫的危险因素。这些病因因素对癫痫的相对风险低于对脑瘫的相对风险。
