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芬兰北部一个1年出生队列中的脑瘫及其他残疾——一项至14岁的前瞻性随访研究

Cerebral palsy and additional handicaps in a 1-year birth cohort from northern Finland--a prospective follow-up study to the age of 14 years.

作者信息

von Wendt L, Rantakallio P, Saukkonen A L, Tuisku M, Mäkinen H

出版信息

Ann Clin Res. 1985;17(4):156-61.

PMID:4073804
Abstract

In a 1-year birth cohort from the two northernmost provinces in Finland, Oulu and Lapland which comprised of 12 058 liveborn infants, the total number of children affected with cerebral palsy (CP) was 69. The cumulative incidence up to the age of 14 years was 5.7 per thousand. A prenatal aetiology was present in 32%, a perinatal aetiology in 36% and a postnatal aetiology in 19% whereas in 13.0% of the cases the cause remained untraceable. A total of 50 children (73%), had 1 or more additional handicaps. Mental retardation (IQ less than 85) was present in 70%, epilepsy in 48%, a visual defect in 19% and impaired hearing in 7%. The impact of the total handicaps is also illustrated by the fact that only 33% of the children were able to attend a normal school. The incidence of 5.7 per thousand recorded here is clearly higher than in studies from several other countries, as the cumulative incidence is usually reported to vary between 2 and 3 per thousand.

摘要

在芬兰最北部的两个省份奥卢和拉普兰进行的一项为期1年的出生队列研究中,共有12058名活产婴儿,其中患脑瘫(CP)的儿童总数为69名。14岁时的累积发病率为千分之5.7。产前病因占32%,围产期病因占36%,产后病因占19%,而13.0%的病例病因不明。共有50名儿童(73%)有1种或更多其他残疾。智力迟钝(智商低于85)的占70%,癫痫的占48%,视力缺陷的占19%,听力受损的占7%。只有33%的儿童能够进入正常学校这一事实也说明了残疾总数的影响。此处记录的千分之5.7的发病率明显高于其他几个国家的研究结果,因为累积发病率通常报告在千分之2至3之间。

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