Graduate School of Health and Sports Science, Juntendo University, Inzai 270-1695, Japan.
Nutrients. 2022 Jul 30;14(15):3144. doi: 10.3390/nu14153144.
Women are prone to iron deficiency because of increased iron excretion associated with menstruation. This is often treated by oral iron supplementation, although this treatment can cause side effects, such as stomach pain and nausea, with low absorption of ingested iron. Previously, a significant increase in serum iron was observed in association with the consumption of foods containing subsp. H61 (H61). However, the causal relationship between H61 ingestion and elevated serum iron is still unclear. Therefore, in this study, we aimed to determine the effects of H61 ingestion on the iron status of young women. Healthy young Japanese women (18-25 years of age) ingested either heat-killed H61 or placebo for 4 weeks. Serum iron, transferrin saturation, and ferritin were significantly elevated in the H61 group but remained unchanged in the placebo group. Compared to before the intervention, iron intake remained unchanged during the intervention period, so the change in the iron status of the H61 group was not due to increased iron intake. These results suggest that heat-killed H61 may elevate iron status by enhancing iron absorption.
女性由于月经导致铁排泄增加，因此容易缺铁。通常通过口服补铁来治疗，但这种治疗可能会引起副作用，如胃痛和恶心，同时摄入的铁吸收不良。以前，人们观察到食用含有 subsp. H61（H61）的食物会显著增加血清铁。然而，H61 摄入与血清铁升高之间的因果关系仍不清楚。因此，在这项研究中，我们旨在确定 H61 摄入对年轻女性铁状况的影响。健康的年轻日本女性（18-25 岁）摄入加热灭活的 H61 或安慰剂，持续 4 周。H61 组的血清铁、转铁蛋白饱和度和铁蛋白显著升高，而安慰剂组则保持不变。与干预前相比，干预期间铁的摄入量保持不变，因此 H61 组铁状况的变化不是由于铁摄入量的增加。这些结果表明，加热灭活的 H61 可能通过增强铁吸收来提高铁水平。
