Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Lund University, 21428 Malmö, Sweden.
Department of Public Health and Clinical Medicine, Umeå University, 90187 Umeå, Sweden.
Nutrients. 2022 Aug 1;14(15):3171. doi: 10.3390/nu14153171.
People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a person's degree of resilience or sensitivity to adverse lifestyle exposures and determine whether these classifications help predict cardiometabolic disease later in life; we pooled data from two population-based Swedish prospective cohort studies (n = 53,507), and we contrasted an individual's cardiometabolic biomarker profile with the profile predicted for them given their lifestyle exposure characteristics using a quantile random forest approach. People who were classed as 'sensitive' to hypertension- and dyslipidemia-related lifestyle exposures were at higher risk of developing cardiovascular disease (CVD, hazards ratio 1.6 (95% CI: 1.3, 1.91)), compared with the general population. No differences were observed for type 2 diabetes (T2D) risk. Here, we report a novel approach to identify individuals who are especially sensitive to adverse lifestyle exposures and who are at higher risk of subsequent cardiovascular events. Early preventive interventions may be needed in this subgroup.
人们似乎对心血管代谢疾病的生活方式风险因素有不同的易感性；确定谁最敏感可能有助于优化预防干预的时机、设计和实施。我们旨在确定一个人对不良生活方式暴露的适应能力或敏感性程度，并确定这些分类是否有助于预测日后的心血管代谢疾病；我们对两项基于人群的瑞典前瞻性队列研究的数据进行了汇总（n=53507），并使用分位数随机森林方法对比了个体的心血管代谢生物标志物特征与其根据生活方式暴露特征预测的特征。与一般人群相比，被归类为对高血压和血脂异常相关生活方式暴露“敏感”的人群患心血管疾病（CVD，风险比 1.6（95%CI：1.3，1.91））的风险更高。对于 2 型糖尿病（T2D）风险则未观察到差异。在这里，我们报告了一种识别对不良生活方式暴露特别敏感且随后发生心血管事件风险较高的个体的新方法。在这个亚组中可能需要早期预防干预。
