Zhu Hongkang, Liu Chang, Qian He
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi 214122, China.
Plants (Basel). 2022 Jul 31;11(15):2004. doi: 10.3390/plants11152004.
Natural plants from plateaus have been the richest source of secondary metabolites extensively used in traditional and modern health care systems. They were submitted to years of natural selection, co-evolved within that habitat, and show significant anti-fatigue-related pharmacological effects. However, currently, no review on high-altitude plants with anti-fatigue related properties has been published yet. This study summarized several Chinese traditional high-altitude plants, including L., L., W., L., which are widely used in the Qinghai-Tibet Plateau and surrounding mountains, as well as herbal markets in the plains. Based on phytopharmacology studies, deeper questions can be further revealed regarding how these plants regulate fatigue and related mental or physical disease conditions. Many active derivatives in high-altitude medical plants show therapeutic potential for the management of fatigue and related disorders. Therefore, high-altitude plants significantly relieve central or peripheral fatigue by acting as neuroprotective agents, energy supplements, metabolism regulators, antioxidant, and inflammatory response inhibitors. Their applications on the highland or flatland and prospects in natural medicine are further forecast, which may open treatments to reduce or prevent fatigue-related disorders in populations with sub-optimal health.
高原天然植物一直是次生代谢产物的最丰富来源，在传统和现代医疗保健系统中广泛应用。它们经历了多年的自然选择，在该栖息地共同进化，并显示出显著的抗疲劳相关药理作用。然而，目前尚未发表关于具有抗疲劳相关特性的高海拔植物的综述。本研究总结了几种中国传统高海拔植物，包括[具体植物名称1]、[具体植物名称2]、[具体植物名称3]、[具体植物名称4]，这些植物在青藏高原及周边山区以及平原的草药市场中广泛使用。基于植物药理学研究，可以进一步揭示这些植物如何调节疲劳以及相关的精神或身体疾病状况等更深层次的问题。高海拔药用植物中的许多活性衍生物对疲劳及相关疾病的治疗具有潜在作用。因此，高海拔植物通过充当神经保护剂、能量补充剂、代谢调节剂、抗氧化剂和炎症反应抑制剂，显著缓解中枢或外周疲劳。进一步预测了它们在高原或平原的应用以及在天然药物中的前景，这可能为减少或预防健康欠佳人群中与疲劳相关的疾病开辟治疗途径。
