Avramia Ionut, Amariei Sonia
Faculty of Food Engineering, Stefan cel Mare University of Suceava, 720229 Suceava, Romania.
Plants (Basel). 2022 Aug 4;11(15):2040. doi: 10.3390/plants11152040.
The aim of this study was to develop fast dissolving films based on β-glucan and bilberry juice due to the bioactive potential of β-glucan and antidiabetic effect of bilberry juice. The benefit of incorporation of bioactive compounds into the films is due to the removal of unnecessary excipients and to confer protection as well as increase stability and shelf life to the packaged product. Due to the fast dissolving requirements of the European Pharmacopeia, which reduced the dissolution time from 180 to 60 s, indicating less than a minute, hygroscopic materials, such as sodium alginate and a suitable plasticizer, such as glycerin were incorporated. Moreover, the influence of ingredients and surfactants, such as soybean oil was studied in the design of fast dissolving films. Additionally, the steady state rate water vapor transmission rate (WVTR), water vapor permeability (WVP), and FT-IR spectroscopy tests were performed at high resolution to ensure the reliability of the films and composition as well as to validate the results. Our data suggest that the addition of surfactants contributed to the development of fast dissolving films without influencing the diffusion of water vapor. Low levels of WVTR and short dissolution time made from β-glucan and bilberry juice are a convenient candidate for packaging dry powdered pharmaceuticals for diabetes.
由于β-葡聚糖的生物活性潜力和越橘汁的抗糖尿病作用，本研究的目的是开发基于β-葡聚糖和越橘汁的速溶薄膜。将生物活性化合物掺入薄膜中的好处在于去除了不必要的辅料，并为包装产品提供保护，以及提高稳定性和保质期。由于欧洲药典对速溶的要求，将溶解时间从180秒缩短至60秒（即不到一分钟），因此加入了吸湿材料，如海藻酸钠和合适的增塑剂，如甘油。此外，在速溶薄膜的设计中研究了成分和表面活性剂（如大豆油）的影响。另外，进行了高分辨率的稳态水蒸气透过率（WVTR）、水蒸气透过系数（WVP）和傅里叶变换红外光谱测试，以确保薄膜和成分的可靠性，并验证结果。我们的数据表明，表面活性剂的添加有助于速溶薄膜的开发，而不影响水蒸气的扩散。由β-葡聚糖和越橘汁制成的低水平WVTR和短溶解时间使其成为糖尿病干粉状药物包装的便利选择。
