基于透明质酸与牛血清白蛋白分子相互作用的新型材料。
New Materials Based on Molecular Interaction between Hyaluronic Acid and Bovine Albumin.
机构信息
Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Toruń, Poland.
Institute of Mathematics and Physics, Faculty of Chemical Technology and Engineering, Bydgoszcz University of Technology J.J. Śniadeckich, 85-796 Bydgoszcz, Poland.
出版信息
Molecules. 2022 Aug 4;27(15):4956. doi: 10.3390/molecules27154956.
In this work, the interactions between hyaluronic acid and bovine serum albumin were investigated. The film-forming properties of the mixture were proven, and the mechanical and surface properties of the films were measured. The results showed the interactions between hyaluronic acid and albumin, mainly by hydrogen bonds. Molecular docking was used for the visualization of the interactions. The films obtained from the mixture of hyaluronic acid possessed different properties to films obtained from the single component. The addition of bovine serum albumin to hyaluronic acid led to a decrease in the mechanical properties, and to an increase in the surface roughness of the film. The new materials that have been obtained by blending can form a new group of materials for biomedicine and cosmetology.
本工作研究了透明质酸与牛血清白蛋白之间的相互作用。证明了混合物的成膜性能，并测量了薄膜的力学和表面性能。结果表明，透明质酸与白蛋白之间的相互作用主要通过氢键发生。分子对接用于可视化相互作用。由透明质酸混合物获得的薄膜具有与由单一成分获得的薄膜不同的性质。向透明质酸中添加牛血清白蛋白会导致机械性能降低，并且薄膜的表面粗糙度增加。通过共混获得的新材料可以形成用于生物医药和化妆品的新材料组。
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