Threlfall E J, Rowe B, Ferguson J L, Ward L R
J Hyg (Lond). 1986 Dec;97(3):419-26. doi: 10.1017/s0022172400063609.
In Salmonella typhimurium phage type 204c isolated in Britain, gentamicin resistance is specified by plasmids of the I1 compatibility group which also confer resistance to apramycin. These plasmids have been subdivided into three types within the I1 group on the basis of their antibiotic resistance specificity, their ability to produce colicin Ib and their restriction enzyme digest fragmentation patterns. All three have been identified in strains from cattle, but as yet only two types have been found in strains from humans. It is suggested that the use of apramycin in animal husbandry is responsible for the appearance of gentamicin resistance in multiresistant strains of phage type 204c, a phage type already epidemic in bovine animals and with an increasing incidence in humans.
在英国分离出的鼠伤寒沙门氏菌204c型噬菌体中，庆大霉素耐药性由I1相容群的质粒决定，这些质粒还赋予对阿泊拉霉素的耐药性。根据其抗生素耐药特异性、产生大肠杆菌素Ib的能力以及限制性内切酶消化片段模式，这些质粒在I1组内被细分为三种类型。所有这三种类型都在牛的菌株中被鉴定出来，但到目前为止，在人类菌株中仅发现了两种类型。有人认为，畜牧业中使用阿泊拉霉素导致了204c型噬菌体多重耐药菌株中庆大霉素耐药性的出现，204c型噬菌体在牛群中已经流行，且在人类中的发病率不断上升。
