Smock T, Cach R, Topple A
Exp Brain Res. 1987;66(2):401-8. doi: 10.1007/BF00243314.
Arginine vasopressin is reported to have an excitatory effect on hippocampal neurons in the slice preparation. However, vasopressin also has a classic vasopressor action on mammalian blood vessels. We used the rat hippocampal slice to examine the effects of this peptide on central neural and vascular targets. The hippocampus is densely vascularized and pyramidal cells are enmeshed in a network of microvessels. Vasopressin increased the excitability of impaled neurons without substantially altering membrane potential or resistance. The peptide also caused pronounced vasoconstriction in penetrating microvessels when applied at micromolar concentrations. The concerted action of vasopressin on neurons and blood vessels and the physical proximity of these cell types suggest mechanisms whereby these responses may be associated.
据报道，精氨酸加压素对脑片制备中的海马神经元具有兴奋作用。然而，加压素对哺乳动物血管也具有典型的升压作用。我们使用大鼠海马脑片来研究这种肽对中枢神经和血管靶点的影响。海马血管密集，锥体细胞嵌入微血管网络中。加压素增加了刺入神经元的兴奋性，而没有实质性改变膜电位或电阻。当以微摩尔浓度应用时，该肽还会导致穿透性微血管出现明显的血管收缩。加压素对神经元和血管的协同作用以及这些细胞类型在物理上的接近性提示了这些反应可能相关的机制。
