Wang Jiao, Yang Yuchun, Zhang Lei, He Pengyi, Mu Huyati
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Cardiol Res Pract. 2022 Jul 31;2022:7845108. doi: 10.1155/2022/7845108. eCollection 2022.
Stent restenosis after PCI seriously affects the efficacy and prognosis; therefore, the study of ISR risk factors has become an urgent topic to be solved.
To investigate the risk factors for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in Han and Uygur patients with coronary heart disease.
The clinical data of 345 Han and 127 Uygur patients who underwent intracoronary stent implantation were divided into an ISR group and a non-ISR group. The general clinical data, laboratory indicators, and coronary artery lesions were compared.
Age (OR = 1.040, 95% CI: 1.006∼1.075), triglycerides (OR = 1.440, 95% CI: 1.050∼1.973), total cholesterol (OR = 5.256, 95% CI: 2.826∼9.773), and ApoB (OR = 137.540, 95% CI: 11.364∼899.455) were independent risk factors for ISR after PCI in the Han patients, while ApoAI (OR = 0.002, 95% CI: 0.001∼0.011), MCV (OR = 0.824, 95% CI: 0.744∼0.911), MCH (OR = 0.421, 95% CI: 0.324∼0.548), and MCHC (OR = 0.934, 95% CI: 0.903∼0.965) were protective factors of ISR after PCI in Han patients, and the logistic regression equation composed of various factors predicted that the area under the ROC curve of ISR was 0.905. ApoB (OR = 11.571, 95% CI: 1.667∼80.340), Gensini score (OR = 1.017, 95% CI: 1.003∼1.031), and diabetes history (OR = 3.474, 95% CI: 1.189∼10.151) were independent risk factors for ISR after PCI in Uygur patients, and the area under ROC curve of ISR predicted by logistic regression equation is 0.807. The predictive efficiency of the Gensini score and ApoB level for ISR in Uygur patients was higher than that in Han, while the predictive efficiency of levels of ApoAI and MCH for ISR in Han patients was higher than that in Uygur ( < 0.05).
The independent risk factors for ISR after PCI in Han and Uygur patients in Xinjiang are different.
经皮冠状动脉介入治疗（PCI）后支架再狭窄严重影响疗效及预后，因此，研究支架内再狭窄（ISR）的危险因素已成为亟待解决的课题。
探讨新疆汉族和维吾尔族冠心病患者PCI术后支架内再狭窄（ISR）的危险因素。
将345例汉族和127例维吾尔族接受冠状动脉内支架植入术患者的临床资料分为ISR组和非ISR组，比较一般临床资料、实验室指标及冠状动脉病变情况。
汉族患者PCI术后ISR的独立危险因素为年龄（OR = 1.040，95%CI：1.006～1.075）、甘油三酯（OR = 1.440，95%CI：1.050～1.973）、总胆固醇（OR = 5.256，95%CI：2.826～9.773）和载脂蛋白B（ApoB，OR = 137.540，95%CI：11.364～899.455），而载脂蛋白AI（ApoAI，OR = 0.002，95%CI：0.001～0.011）、平均红细胞体积（MCV，OR = 0.824，95%CI：0.744～0.911）、平均红细胞血红蛋白含量（MCH，OR = 0.421，95%CI：0.324～0.548）和平均红细胞血红蛋白浓度（MCHC，OR = 0.934，95%CI：0.903～0.965）是汉族患者PCI术后ISR的保护因素，由各因素组成的logistic回归方程预测ISR的ROC曲线下面积为0.905。维吾尔族患者PCI术后ISR的独立危险因素为ApoB（OR = 11.571，95%CI：1.667～80.340）、Gensini评分（OR = 1.017，95%CI：1.003～1.031）和糖尿病史（OR = 3.474，95%CI：1.189～10.151），logistic回归方程预测ISR的ROC曲线下面积为0.807。Gensini评分和ApoB水平对维吾尔族患者ISR的预测效率高于汉族，而ApoAI和MCH水平对汉族患者ISR的预测效率高于维吾尔族（P<0.05）。
新疆汉族和维吾尔族患者PCI术后ISR的独立危险因素不同。
