Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Hematology and Transfusion Science Research Center (HTSRC), Walailak University, Nakhon Si Thammarat 80160, Thailand.
ScientificWorldJournal. 2022 Jul 31;2022:8924023. doi: 10.1155/2022/8924023. eCollection 2022.
infection causes gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma, and gastric cancer and can also promote thrombosis. It is estimated that approximately 4.5 billion individuals are infected, thus rendering the most prevalent microbial pathogen. Currently established regimes for antibiotic treatment are massively challenged by increasing drug resistance and the development of novel antimicrobial therapies is urgently required. The antibiotic capreomycin is clinically used against multiple drug-resistant strains of . It targets the complex between TlyA, a hemolysin- and RNA-binding protein, and the bacterial rRNA. In this study we have explored the possible antibacterial effects of capreomycin against several strains of and found only moderate activity which was comparable to metronidazole-resistant strains. Molecular docking of capreomycin to TlyA proteins from and identified several residues within TlyA which interact with the drug; however, binding affinities of - TlyA for capreomycin appear to be higher than those of - TlyA. The data suggest that capreomycin may warrant further investigations into its potential use as antibiotic against
感染可导致胃炎、消化性溃疡病、黏膜相关淋巴组织淋巴瘤和胃癌，并可促进血栓形成。据估计，约有 45 亿人受到感染，使其成为最普遍的微生物病原体。目前用于抗生素治疗的方案正受到耐药性不断增加的巨大挑战，迫切需要开发新的抗菌疗法。抗生素卷曲霉素临床上用于治疗多种耐药菌株。它针对 TlyA（一种溶血素和 RNA 结合蛋白）与细菌 rRNA 之间的复合物。在这项研究中，我们探索了卷曲霉素对几种菌株的可能抗菌作用，发现只有适度的活性，与甲硝唑耐药菌株相当。卷曲霉素与来自 和 的 TlyA 蛋白的分子对接确定了 TlyA 中与药物相互作用的几个残基；然而，- TlyA 与卷曲霉素的结合亲和力似乎高于 - TlyA。数据表明，卷曲霉素可能值得进一步研究其作为抗生素治疗的潜力。
