is with the High-Dependency Unit, Tan Tock Seng Hospital, National Health Group, Singapore.
are with the Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Nutr Rev. 2023 Feb 10;81(3):287-303. doi: 10.1093/nutrit/nuac055.
The prevalence of age-related cognitive decline has been on the rise as the global population age, putting the independence and quality of life of elderly at risk. Anthocyanin, as a subclass of dietary flavonoids, may have a beneficial impact on cognitive outcomes.
To examine the effects of dietary anthocyanin supplementation on cognition of the cognitively healthy middle-aged and older adults.
PubMed, ScienceDirect, CINAHL, EMBASE, ProQuest and Cochrane databases were searched.
Thirteen studies were included in this meta-analysis. Anthocyanin-rich supplementation was found to significantly improve the processing speed of the older adults (95%CI 0.08, 0.44; P = 0.004). No significant differences were observed between intervention and control groups on memory, attention, executive function and psychomotor performance. Current neuroimaging studies have found promising effects of anthocyanin supplementation on brain activation and cerebral perfusion.
Anthocyanin-rich supplementation may preserve cognitive processing speed and neuro-activities in older adults, which improves their daily functioning and quality of life. This review provides useful insights to guide direction and methodological designs for future studies to explore the underlying mechanisms of anthocyanins.
SYSTEMATIC REVIEW AND META-ANALYSIS REGISTRATION: PROSPERO registration No. CRD42021228007.
随着全球人口老龄化，与年龄相关的认知能力下降的患病率呈上升趋势，这使老年人的独立性和生活质量面临风险。花色苷作为类黄酮的一个亚类，可能对认知结果有有益的影响。
研究花色苷饮食补充对认知健康的中老年人群认知的影响。
对 PubMed、ScienceDirect、CINAHL、EMBASE、ProQuest 和 Cochrane 数据库进行了检索。
这项荟萃分析纳入了 13 项研究。研究发现，花色苷丰富的补充剂可显著提高老年人的加工速度（95%CI 0.08，0.44；P=0.004）。干预组和对照组在记忆、注意力、执行功能和运动表现方面无显著差异。目前的神经影像学研究发现，花色苷补充剂对大脑激活和脑灌注有积极影响。
花色苷丰富的补充剂可能有助于保持老年人的认知加工速度和神经活动，从而提高他们的日常生活功能和生活质量。本综述为指导未来研究提供了有用的见解，以探索花色苷的潜在机制。
PROSPERO 注册号 CRD42021228007。
