Zhang Shuang, Li Nan, Li Weiqin, Wang Leishen, Liu Enqing, Zhang Tao, Dong Wei, Chen Jiujing, Leng Junhong
Tianjin Women's and Children's Health Center, Tianjin, People's Republic of China.
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Aug 8;15:2353-2363. doi: 10.2147/DMSO.S374427. eCollection 2022.
We aim to investigate the influence of weight gain during pregnancy on the risk of offspring adiposity before five years old.
We retrospectively collected health information from the Tianjin mother-child cohort. Offspring outcome was BMI -score and prevalence of childhood adiposity from 0.5-5 years old. Gestational weight gain was analyzed using continuous and categorical variables evaluated by the IOM guidelines. Multivariate analysis adjusted maternal age, prepregnancy BMI, maternal height, smoking, cesarean section, gestational age at birth, birth weight, birth length, and mode of infant feeding during 0-6 months.
Gestational weight gain contributed to offspring's BMI -score from 1-5 years old, and the effect was most obvious in the first half of pregnancy (multivariate analysis, at 1, 2, 2.5, 3, 4, and 5 years of age: 0.011, 95% CI 0.008-0.014; 0.017, 95% CI 0.015-0.020; 0.005, 95%CI 0.002-0.008; 0.018, 95% CI 0.015-0.021; 0.014, 95% CI 0.009-0.020; 0.013, 95% CI 0.005-0.021). Excessive weight gain was associated with a higher prevalence of offspring adiposity before five years, even if prepregnancy BMI is normal. Multivariate regression analysis further confirmed that excessive weight gain during the first half of pregnancy significantly increased the risk of childhood obesity at aged one and three (AOR 1.083, 95% CI 1.003-1.169; AOR 1.158, 95% CI 1.036-1.293).
Offspring have a higher risk of preschool adiposity when gestational weight gain was excessive during the first half of pregnancy.
我们旨在研究孕期体重增加对5岁前后代肥胖风险的影响。
我们回顾性收集了天津母婴队列的健康信息。后代的结局指标为0.5至5岁时的BMI评分和儿童肥胖患病率。使用由美国医学研究所（IOM）指南评估的连续变量和分类变量分析孕期体重增加情况。多变量分析调整了母亲年龄、孕前BMI、母亲身高、吸烟情况、剖宫产、出生时的孕周、出生体重、出生身长以及0至6个月时的婴儿喂养方式。
孕期体重增加对1至5岁后代的BMI评分有影响，且在孕早期影响最为明显（多变量分析，在1、2、2.5、3、4和5岁时：0.011，95%置信区间0.008 - 0.014；0.017，95%置信区间0.015 - 0.020；0.005，95%置信区间0.002 - 0.008；0.018，95%置信区间0.015 - 0.021；0.014，95%置信区间0.009 - 0.020；0.013，95%置信区间0.005 - 0.021）。即使孕前BMI正常，体重过度增加也与5岁前后代肥胖患病率较高相关。多变量回归分析进一步证实，孕早期体重过度增加显著增加了1岁和3岁时儿童肥胖的风险（比值比1.083，95%置信区间1.003 - 1.169；比值比1.158，95%置信区间1.036 - 1.293）。
当孕早期孕期体重过度增加时，后代学龄前肥胖的风险更高。
