Centro de Genómica y Bioinformática, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Huechuraba, Chile.
Escuela de Biotecnología, Facultad de Ciencias, Ingeniería y Tecnología, Universidad Mayor, Santiago, Chile.
Front Cell Infect Microbiol. 2022 Jul 29;12:964710. doi: 10.3389/fcimb.2022.964710. eCollection 2022.
The mammalian gut microbiota comprises a variety of commensals including potential probiotics and pathobionts, influencing the host itself. Members of the microbiota can intervene with host physiology by several mechanisms, including the secretion of a relatively well-reported set of metabolic products. Another microbiota influence mechanism is the use of secreted proteins (i.e., the secretome), impacting both the host and other community members. While widely reported and studied in pathogens, this mechanism remains understood to a lesser extent in commensals, and this knowledge is increasing in recent years. In the following minireview, we assess the current literature covering different studies, concerning the functions of secretable proteins from members of the gut microbiota (including commensals, pathobionts, and probiotics). Their effect on host physiology and health, and how these effects can be harnessed by postbiotic products, are also discussed.
哺乳动物肠道微生物群包含多种共生菌，包括潜在的益生菌和条件致病菌，影响宿主自身。微生物群的成员可以通过多种机制干预宿主生理学，包括分泌一组相对报道较多的代谢产物。另一种微生物群影响机制是利用分泌蛋白（即分泌组），影响宿主和其他群落成员。虽然在病原体中被广泛报道和研究，但在共生菌中，这种机制的了解程度较低，近年来这方面的知识正在增加。在下面的迷你综述中，我们评估了涵盖不同研究的现有文献，这些研究涉及肠道微生物群（包括共生菌、条件致病菌和益生菌）成员可分泌蛋白质的功能。还讨论了它们对宿主生理学和健康的影响，以及如何利用后生元产品利用这些影响。
