School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Henan Engineering Research Center of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Influenza Other Respir Viruses. 2023 Aug;17(8):e13180. doi: 10.1111/irv.13180.
The economic burden of respiratory syncytial virus (RSV) infection and its impact on health-related quality of life (HRQoL) are not well-understood in China. This study assessed total cost and HRQoL for children hospitalized with RSV in Central China.
Based on a prospective case series study in Henan Province in 2020-2021, inpatients aged 0-59 months with RSV-related acute respiratory infections (ARIs) were included into analysis. Total cost included direct medical cost (sum of medical cost before and during hospitalization), direct non-medical cost, and indirect cost. Direct medical cost during hospitalization data were extracted from the hospital information system. Other costs and HRQoL status were obtained from a telephone survey conducted in the caregivers of the enrolled patients.
Among 261 RSV-infected inpatients, caregivers of 170 non-severe cases (65.1%, 170/261) were successfully interviewed. Direct medical cost per episode was 1055.3 US dollars (US$) (95% CI: 998.2-1112.5 US$). Direct non-medical cost and indirect cost per episode were 83.6 US$ (95% CI: 77.5-89.7 US$) and 162.4 US$ (95% CI: 127.9-197.0 US$), respectively. Quality adjusted life years (QALY) loss for non-severe RSV hospitalization was 8.9 × 10 (95% CI: 7.9 × 10 -9.9 × 10 ). The majority of inpatients were <1 year of age comprising significantly higher cost and more QALY loss than older children.
RSV-associated hospitalization poses high economic and health burden in Central China particularly for children <1 year old. Our findings are crucial for determining the priority of interventions and allocation of health resources.
在中国，呼吸道合胞病毒（RSV）感染的经济负担及其对健康相关生活质量（HRQoL）的影响尚未得到充分了解。本研究评估了中国中部地区因 RSV 住院的儿童的总费用和 HRQoL。
基于 2020-2021 年在河南省进行的一项前瞻性病例系列研究，纳入了年龄在 0-59 个月、患有 RSV 相关急性呼吸道感染（ARI）的住院患者。总费用包括直接医疗费用（住院前和住院期间医疗费用总和）、直接非医疗费用和间接费用。住院期间的直接医疗费用数据从医院信息系统中提取。其他费用和 HRQoL 状况从对纳入患者的照顾者进行的电话调查中获得。
在 261 例 RSV 感染住院患者中，有 170 例（65.1%，170/261）非重症病例的照顾者接受了成功访谈。每个病例的直接医疗费用为 1055.3 美元（95%CI：998.2-1112.5 美元）。每个病例的直接非医疗费用和间接费用分别为 83.6 美元（95%CI：77.5-89.7 美元）和 162.4 美元（95%CI：127.9-197.0 美元）。非重症 RSV 住院的健康调整生命年（QALY）损失为 8.9×10（95%CI：7.9×10-9.9×10）。大多数住院患者年龄<1 岁，其费用和 QALY 损失明显高于年龄较大的儿童。
在中国中部地区，RSV 相关住院治疗对儿童（尤其是<1 岁的儿童）造成了沉重的经济和健康负担。我们的研究结果对于确定干预措施的优先级和卫生资源的分配至关重要。
