Bottoni F G, Staurenghi G, Orzalesi N
Int Ophthalmol. 1987 Jun;10(3):167-73. doi: 10.1007/BF00139344.
A 71-year-old man presented with a large disciform scar in the right eye and hard (nodular) as well as soft (granular) drusen scattered throughout the posterior pole of the left eye. A large serous pigment epithelial detachment was evident in the drusen area of the left fundus. Six months later a tear of the retinal pigment epithelium (RPE) occurred in the left eye. It was located exactly along the peripheral border of the drusen area instead of the border of the RPE detachment where it would have been expected. It is considered that reduced adhesion between the RPE and Bruch's membrane as well as the sharp change in tissue cohesiveness at the border of the drusen area and surrounding healthy tissue were relevant in the pathogenesis of this case.
一名71岁男性，右眼有一个大的盘状瘢痕，左眼后极部散在分布着硬性（结节状）和软性（颗粒状）玻璃膜疣。左眼玻璃膜疣区域可见一个大的浆液性色素上皮脱离。6个月后，左眼发生视网膜色素上皮（RPE）撕裂。撕裂恰好位于玻璃膜疣区域的周边边界，而非预期的RPE脱离边界处。据认为，RPE与 Bruch膜之间的粘连降低以及玻璃膜疣区域与周围健康组织边界处组织内聚力的急剧变化与该病例的发病机制有关。
