Stepanski E, Lamphere J, Roehrs T, Zorick F, Roth T
Int J Neurosci. 1987 Apr;33(3-4):207-14. doi: 10.3109/00207458708987405.
Recent research has suggested that sleep fragmentation in the absence of sleep loss is an important cause of excessive daytime sleepiness in certain clinical populations (e.g., sleep apnea syndrome or periodic leg movements). This study experimentally varied the number and rate of arousals in sleep to define more clearly the relation of sleep fragmentation and daytime sleepiness. Five male subjects participated in the study. Data from each were recorded for three consecutive nights (one baseline followed by two experimental nights) under three experimental conditions. All nocturnal polysomnograms were followed by a Multiple Sleep Latency Test (MSLT) the next day. The experimental conditions consisted of three different schedules of arousal produced by series of tones presented to subjects over headphones. The MSLT showed statistically significant changes after two nights of fragmented sleep, but the three fragmentation schedules did not differ from each other. Arousal threshold also changed significantly with sleep fragmentation from night one to night two.
最近的研究表明，在没有睡眠缺失的情况下，睡眠片段化是某些临床人群（如睡眠呼吸暂停综合征或周期性腿部运动）日间过度嗜睡的一个重要原因。本研究通过实验改变睡眠中觉醒的次数和频率来更清楚地界定睡眠片段化与日间嗜睡之间的关系。五名男性受试者参与了该研究。在三种实验条件下，连续三晚（一晚基线期，随后两晚实验期）记录每个人的数据。所有夜间多导睡眠图记录次日均进行多次睡眠潜伏期测试（MSLT）。实验条件包括通过耳机向受试者播放一系列音调产生的三种不同的觉醒时间表。经过两晚的睡眠片段化后，MSLT显示出具有统计学意义的变化，但三种片段化时间表之间没有差异。从第一晚到第二晚，觉醒阈值也随着睡眠片段化而显著变化。
