Panati Kalpana, Timmana Lokesh V, Reddy AT Venkatramana, Reddy Saddala Rajeswara, Ramireddy Narala Venkata
Department of Biotechnology, Government College for Men, Kadapa, A.P, India
Department of Zoology, Yogi Vemana University, Kadapa, A.P, India
Eurasian J Med. 2022 Oct;54(3):299-304. doi: 10.5152/eurasianjmed.2022.21133.
The pandemic coronavirus disease 2019 outbreak's causative agent was identified as severe acute respiratory syndrome coronavirus 2. It is a positive-sense single-stranded RNA virus with a ~30 kb size genome that belongs to the Nidovirales. Molecular analysis revealed that severe acute respiratory syndrome coronavirus 2 is a variant of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus with some sequence similarity. The confirmed cases and death toll are high in severe acute respiratory syndrome coronavirus 2 compared to severe acute respiratory syndrome coronavirus and the estimated R0 is >1. The data on pathological findings on severe acute respiratory syndrome coronavirus 2 are scarce and present treatment management is based on symptoms that are similar to severe acute respiratory syndrome coronavirus. In this review, we have discussed the transmission, viral replication, and cytokine storm and highlighted the recent pathological findings of coronavirus disease 2019. The reported severe acute respiratory syndrome coronavirus 2 pathological findings were similar to that of severe acute respiratory syndrome coronavirus. Though these findings help notify the clinical course of the disease, it warrants further in vivo and ex vivo studies with larger samples obtained from the coronavirus disease 2019 patients.
2019年大流行性冠状病毒病疫情的病原体被确定为严重急性呼吸综合征冠状病毒2。它是一种正链单链RNA病毒，基因组大小约为30 kb，属于尼多病毒目。分子分析显示，严重急性呼吸综合征冠状病毒2是严重急性呼吸综合征冠状病毒和中东呼吸综合征冠状病毒的变种，具有一些序列相似性。与严重急性呼吸综合征冠状病毒相比，严重急性呼吸综合征冠状病毒2的确诊病例和死亡人数较高，估计R0大于1。关于严重急性呼吸综合征冠状病毒2的病理结果的数据很少，目前的治疗管理是基于与严重急性呼吸综合征冠状病毒相似的症状。在这篇综述中，我们讨论了传播、病毒复制和细胞因子风暴，并强调了2019年冠状病毒病的最新病理结果。报告的严重急性呼吸综合征冠状病毒2的病理结果与严重急性呼吸综合征冠状病毒相似。尽管这些发现有助于了解疾病的临床过程，但仍需要对从2019年冠状病毒病患者中获得的更大样本进行进一步的体内和体外研究。
